Granger D N
Department of Molecular and Cellular Physiology, Louisiana State University Medical Center, Shreveport 71130-3932, USA.
Am J Physiol. 1997 Nov;273(5):G982-6. doi: 10.1152/ajpgi.1997.273.5.G982.
The adhesion of leukocytes to vascular endothelial cells is a highly coordinated process that is governed by a number of factors, including the expression of specific adhesion glycoproteins, physical forces generated within the microcirculation, and inflammatory mediators released by a variety of activated cells. The digestive system, with its large resident population of immune cells and its tremendous capacity to generate inflammatory mediators, has proven to be a valuable source of information on the mechanisms involved in the regulation of leukocyte-endothelial cell adhesion. This article considers some of the evolving issues that have surfaced as a consequence of the rapidly growing body of literature on this topic. Particular emphasis is devoted to unresolved issues related to the expression and shedding of endothelial cell adhesion molecules, the contribution of capillaries to the inflammatory response, and the role of mast cells, macrophages and lymphocytes in the modulation of leukocyte-endothelial cell adhesion.
白细胞与血管内皮细胞的黏附是一个高度协调的过程，受多种因素调控，包括特定黏附糖蛋白的表达、微循环中产生的物理力以及多种活化细胞释放的炎症介质。消化系统拥有大量常驻免疫细胞，且具有产生炎症介质的巨大能力，已被证明是研究白细胞 - 内皮细胞黏附调控机制的宝贵信息来源。本文探讨了随着该主题文献数量迅速增加而出现的一些新问题。特别强调了与内皮细胞黏附分子的表达和脱落、毛细血管对炎症反应的贡献以及肥大细胞、巨噬细胞和淋巴细胞在调节白细胞 - 内皮细胞黏附中的作用相关的未解决问题。
