Sladek T L
Department of Microbiology and Immunology, Finch University of Health Sciences, Chicago Medical School, Illinois 60064-3095, USA.
Cell Prolif. 1997 Mar-Apr;30(3-4):97-105. doi: 10.1046/j.1365-2184.1997.00085.x.
E2F transcription factors regulate expression of a panel of cellular genes that control cellular DNA synthesis and proliferation, either by activating or repressing their transcription, largely in a cell cycle-dependent manner. The ability of E2F proteins to regulate expression of these target genes is, in turn, regulated by other cellular proteins that are important for normal control of cell cycle progression. Together, E2F proteins, their target genes, and the proteins that regulate E2F activity comprise a genetic pathway that is probably the most, frequently altered pathway in human cancer. This review examines this genetic pathway and focuses on the role of E2F proteins in its function. Specifically, the target genes regulated by E2F, the likely mechanisms by which activation and repression of target gene transcription is achieved, and the regulation of E2F activity by other proteins in the cell, are discussed.
E2F转录因子通过激活或抑制转录，主要以细胞周期依赖性方式调控一组控制细胞DNA合成和增殖的细胞基因的表达。反过来，E2F蛋白调控这些靶基因表达的能力又受到其他对细胞周期进程正常调控很重要的细胞蛋白的调节。E2F蛋白、它们的靶基因以及调节E2F活性的蛋白共同构成了一条遗传途径，这可能是人类癌症中最常发生改变的途径。本综述研究了这条遗传途径，并着重探讨了E2F蛋白在其功能中的作用。具体而言，讨论了E2F调控的靶基因、实现靶基因转录激活和抑制的可能机制，以及细胞中其他蛋白对E2F活性的调节。
