Kixmiller J S, Verfaellie M, Chase K A, Cermak L S
Memory Disorders Research Center, Boston University School of Medicine, Massachusetts 02130, USA.
J Int Neuropsychol Soc. 1995 Nov;1(6):561-7. doi: 10.1017/s1355617700000692.
To examine the contribution of memory deficits and executive dysfunction to the production of prior-item intrusion errors, Korsakoff, mesial temporal amnesic, and anterior communicating artery aneurysm (ACoA) patients' performance on the Visual Reproduction subtest of the Wechsler Memory Scale-Revised (WMS-R) was assessed. The Korsakoff patients were matched to the mesial temporal group in terms of severity of amnesia, while the ACoA group, which was less severely amnesic, was matched to the Korsakoff group in their performance on executive tests. Results indicated that at immediate recall, Korsakoff patients made significantly more intrusions than mesial temporal and ACoA patients. Conversely, after a delay, ACoA patients tended to make more intrusions than the other groups. Findings suggest that intrusions are due to a combination of deficient memory and executive dysfunction. A further comparison of a subgroup of ACoA patients matched to the Korsakoff patients in terms of severity of amnesia, however, revealed differences in the pattern of intrusions of these two groups, suggesting that different mechanisms may underlie Korsakoff and ACoA patients' susceptibility to interference.
为了探究记忆缺陷和执行功能障碍对先前项目侵入性错误产生的影响，对柯萨科夫综合征患者、颞叶内侧失忆症患者以及前交通动脉瘤（ACoA）患者在韦氏记忆量表修订版（WMS-R）视觉再现子测验中的表现进行了评估。柯萨科夫综合征患者在失忆严重程度上与颞叶内侧组相匹配，而失忆程度较轻的ACoA组在执行测试中的表现与柯萨科夫综合征组相匹配。结果表明，在即时回忆时，柯萨科夫综合征患者比颞叶内侧和ACoA患者出现的侵入性错误显著更多。相反，延迟后，ACoA患者比其他组更容易出现侵入性错误。研究结果表明，侵入性错误是记忆缺陷和执行功能障碍共同作用的结果。然而，对一组在失忆严重程度上与柯萨科夫综合征患者相匹配的ACoA患者亚组进行的进一步比较发现，这两组患者的侵入性错误模式存在差异，这表明柯萨科夫综合征患者和ACoA患者易受干扰的机制可能不同。
