Weber A, Jermini C, Grandjean E
Am J Public Health. 1976 Jul;66(7):672-6. doi: 10.2105/ajph.66.7.672.
Sixty subjects were exposed to cigaretts smoke produced by a smoking machine in a climatic chamber. The irritating effects were recorded by questionnaire and related to concentrations of CO, formaldehyde, and acroleine. The eyes are most sensitive to these irritants, followed by the nose. Annoyance about air quality, and the desire to open the window or to leave the room proved to be other useful measures of sensitivity. With smoke produced by 10 cigarettes/30 m3 acroleine reaches 0.1 ppm, the threshold limit value for industries; simultaneously, CO and formaldehyde exceed the clean air standards for outdoor air. At this exposure level. 9 per cent of the subjects show a strong or very strong eye irritation, while 78 per cent "wish to leave the room." The most important of the measured irritants seems to be acroleine.
60名受试者在气候舱内接触吸烟机产生的香烟烟雾。通过问卷调查记录刺激效应，并与一氧化碳、甲醛和丙烯醛的浓度相关联。眼睛对这些刺激物最敏感，其次是鼻子。对空气质量的不满以及开窗或离开房间的意愿被证明是其他有用的敏感度衡量指标。当每30立方米产生10支香烟的烟雾时，丙烯醛浓度达到0.1 ppm，这是工业的阈限值；同时，一氧化碳和甲醛超过了室外清洁空气标准。在这种暴露水平下，9%的受试者表现出强烈或非常强烈的眼部刺激，而78%的受试者“希望离开房间”。所测刺激物中最重要的似乎是丙烯醛。
