Huh Y, Kim C, Cho J, Lee W, Kim J, Ahn H
Department of Anatomy, College of Medicine, Kyunghee University, Seoul, South Korea.
Neuroreport. 1997 Sep 8;8(13):2991-4. doi: 10.1097/00001756-199709080-00036.
Age-related changes of NADPH-diaphorase (NADPH-d) and vasoactive intestinal polypeptide (VIP) were examined in the rat brain. Aged (24 months) rats showed a significant decrease in the number of VIP-immunoreactive (IR) neurons in the cerebral cortex when compared with control (4 months) rats. However, the number of NADPH-d-positive neurons was not significantly different in the two groups. Quantitative analysis of cell areas revealed a significant shrinkage of VIP-IR neurons in the aged group, whereas no further cell shrinkage was noted for NADPH-d-positive neurons compared with the control group. These morphometric results demonstrate that NADPH-d-containing neurons are more resistant to aging than the VIP-IR neurons in the cerebral cortex of rats.
研究了大鼠脑中与年龄相关的还原型辅酶Ⅱ黄递酶（NADPH-d）和血管活性肠肽（VIP）的变化。与对照组（4个月）大鼠相比，老年（24个月）大鼠大脑皮质中VIP免疫反应性（IR）神经元的数量显著减少。然而，两组中NADPH-d阳性神经元的数量没有显著差异。细胞面积的定量分析显示，老年组中VIP-IR神经元明显萎缩，而与对照组相比，NADPH-d阳性神经元没有进一步的细胞萎缩。这些形态学结果表明，在大鼠大脑皮质中，含NADPH-d的神经元比VIP-IR神经元更抗老化。
