Ouda L, Nwabueze-Ogbo F C, Druga R, Syka J
Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague.
Neuroreport. 2003 Mar 3;14(3):363-6. doi: 10.1097/00001756-200303030-00013.
Age-related changes in NADPH-diaphorase (NADPH-d)-positive neurons were examined in the auditory cortex of young (3 months old) and very old (36 months old) rats (strain Long Evans). In very old rats a significant reduction was found in the thickness of the auditory cortex, to 54% of that in young animals, as well as changes in the shape and configuration of nerve cell bodies and dendrites. Quantitative analysis demonstrated an age-related increase in the number of dendritic segments and dendritic branching points. The length of dendrites in NADPH-d-positive neurons and their density increased in very old rats. The total number of NADPH-d-positive neurons within the Te 1 and Te 3 fields was 13% lower in the old rats than in the young.
