Newton R, Ferlay J, Beral V, Devesa S S
Imperial Cancer Research Fund, Cancer Epidemiology Unit, Radcliffe Infirmary, Oxford, UK.
Int J Cancer. 1997 Sep 17;72(6):923-30. doi: 10.1002/(sici)1097-0215(19970917)72:6<923::aid-ijc1>3.0.co;2-r.
International population-based cancer incidence data, coded according to the International Classification of Diseases for Oncology (WHO, 1990), were used to describe geographical patterns of incidence of extra-nodal non-Hodgkin's lymphomas. Incidence data from the USA were also used to describe age and sex distribution of lymphomas at different extranodal sites. The percentage of all non-Hodgkin's lymphomas coded as being of extra-nodal origin is between 25% and 35% in most countries, with the stomach, skin and small intestine being the most common extra-nodal sites. In general, the pattern of incidence rates for extra-nodal lymphomas tends to reflect that of other lymphomas. For example, the age incidence curve of each site-specific extra-nodal lymphoma is similar to that of nodal lymphomas, and in countries where total lymphoma incidence is high the incidence of lymphomas at each extra-nodal site also tends to be relatively high. Although specific factors are known to increase the risk of lymphomas at certain anatomical sites, these data suggest that the aetiology of extra-nodal lymphomas is not entirely independent from that of nodal lymphomas.
根据国际肿瘤疾病分类（世界卫生组织，1990年）编码的基于国际人口的癌症发病率数据，用于描述结外非霍奇金淋巴瘤的发病率地理模式。美国的发病率数据也用于描述不同结外部位淋巴瘤的年龄和性别分布。在大多数国家，所有编码为结外起源的非霍奇金淋巴瘤的百分比在25%至35%之间，胃、皮肤和小肠是最常见的结外部位。一般来说，结外淋巴瘤的发病率模式往往反映其他淋巴瘤的模式。例如，每个特定部位结外淋巴瘤的年龄发病率曲线与淋巴结淋巴瘤相似，在淋巴瘤总发病率高的国家，每个结外部位淋巴瘤的发病率也往往相对较高。尽管已知特定因素会增加某些解剖部位淋巴瘤的风险，但这些数据表明，结外淋巴瘤的病因并不完全独立于淋巴结淋巴瘤。
