Jones T, Hanson R P
Avian Dis. 1976 Apr-Jun;20(2):293-8.
If lentogenic (nonplaquing) strains of Newcastle disease virus were inoculated into a monolayer of chicken embryo fibroblasts before velogenic (plaquing) strains, the plaquing of the latter were inhibited partially or completely. An interval of 22 hours between the two inoculations gave greater inhibition than did 1 hour. In general, lentogenic strains grew better at 37 C (inhibited plaquing more effectively) than at 42 C. Enzootic velogenic strains that produce a neurotropic form of the disease in chickens were inhibited more than were exotic velogenic strains that produce a viscerotropic form. The lentogenic strains differed markedly in ability to interfere with velogenic strains.
如果在接种速发型（形成蚀斑的）新城疫病毒株之前，先将缓发型（不形成蚀斑的）新城疫病毒株接种到鸡胚成纤维细胞单层中，那么后者的蚀斑形成会受到部分或完全抑制。两次接种之间间隔22小时比间隔1小时产生的抑制作用更强。一般来说，缓发型毒株在37℃时生长更好（更有效地抑制蚀斑形成），而在42℃时则不然。在鸡中引发嗜神经型疾病的地方流行速发型毒株比引发嗜内脏型的外来速发型毒株受到的抑制作用更强。缓发型毒株在干扰速发型毒株的能力上存在显著差异。
