胆酸、鹅去氧胆酸和脱氧胆酸3-单硫酸盐的制备。
Preparation of the 3-monosulphates of cholic acid, chenodeoxycholic acid and deoxycholic acid.
作者信息
Haslewood E S, Haslewood G A
出版信息
Biochem J. 1976 May 1;155(2):401-4. doi: 10.1042/bj1550401.
Abstract
- The 3-sulphates of cholic, chenodeoxycholic and deoxycholic acids were prepared as crystalline disodium salts. 2. The method described shows that it is possible to prepare specific sulphate esters of polyhydroxy bile acids and to remove protecting acyl groups without removing the sulphate. 3. A study of bile acid sulphate solvolysis showed that none of the usual methods give the original bile acid in major yield in a single step. 4. An understanding of the preparation, properties and methods of solvolysis of bile acid sulphates is basic for investigations of cholestasis and liver disease.
摘要
- 胆酸、鹅去氧胆酸和脱氧胆酸的3-硫酸盐被制备成结晶二钠盐。2. 所描述的方法表明，制备多羟基胆汁酸的特定硫酸酯并在不去除硫酸盐的情况下去除保护酰基是可能的。3. 对胆汁酸硫酸盐溶剂解的研究表明，没有一种常规方法能在一步中以主要产率得到原始胆汁酸。4. 了解胆汁酸硫酸盐的制备、性质和溶剂解方法是胆汁淤积和肝病研究的基础。
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