Ruan H, Li X, Cai W
Department of Physiology, Third Military Medical College, Chongqing.
Zhen Ci Yan Jiu. 1996;21(3):27-31.
The effects of SP on the electric activities of neurons of spinal dorsal horn and the influence of 5-HT, somatostatin (SOM) on the effects of SP were observed in anesthetized rats with multimicropipete and iontophoresis techniques. It was found that: (1) The microiontophoretically administrating of SP could increase spinal dorsal horn unit discharge. (2) The noxious electrical activity of neurons induced by formalin could be inhibited by microiontophoretically applied SP. (3) The microiontophoretically administrating of 5-HT and SOM could inhibit the SP and formalin evoked unit discharge of neurons in spinal dorsal horn. It was suggested that SP took a double-effect part in modulation of pain transmission and analgesia in spinal cord, 5-HT and SOM inhibited the effect of SP and participated in pain modulation of SP.
采用多微电极和离子电泳技术，在麻醉大鼠上观察了P物质（SP）对脊髓背角神经元电活动的影响以及5-羟色胺（5-HT）、生长抑素（SOM）对SP作用的影响。结果发现：（1）离子电泳给予SP可使脊髓背角神经元单位放电增加。（2）离子电泳给予SP可抑制福尔马林诱导的神经元伤害性电活动。（3）离子电泳给予5-HT和SOM可抑制SP和福尔马林诱发的脊髓背角神经元单位放电。提示SP在脊髓痛觉传递和镇痛调制中起双重作用，5-HT和SOM抑制SP的作用并参与SP的痛觉调制。
