Lei Y, Liu J X, Zhou Y W
Xiyuan Hospital, China Academy of Traditional Chinese Medicine, Beijing.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 1996 May;16(5):289-91.
Effect of Yuxintong (YXT) capsule on plasma endothelin(ET), serum nitric oxide (NO) and creatine phosphokinase (CPK) activity in experimental acute myocardial ischemia dogs were observed. The results indicated that in acute myocardial ischemia dogs, the serum CPK activity and plasma ET level increased and serum NO level decreased significantly. In comparing with control, YXT not only could reduce significantly the increased plasma ET content and serum CPK activity, but also increase markedly the producing and releasing of NO, P < 0.05-0.001. Therefore, it could protect the myocardia from ischemic damage, the efficacy of YXT was positively dose dependent.
观察了愈心痛（YXT）胶囊对实验性急性心肌缺血犬血浆内皮素（ET）、血清一氧化氮（NO）及肌酸磷酸激酶（CPK）活性的影响。结果表明，急性心肌缺血犬血清CPK活性及血浆ET水平升高，血清NO水平显著降低。与对照组相比，YXT不仅能显著降低升高的血浆ET含量及血清CPK活性，还能显著增加NO的生成与释放，P<0.05 - 0.001。因此，其可保护心肌免受缺血损伤，YXT的疗效呈正剂量依赖性。
