Br Med J. 1976 Jul 3;2(6026):35-7. doi: 10.1136/bmj.2.6026.35.
In a diabetes survey in 1960-1, 808 patients from a whole-practice population who either had glycosuria or were used as age- and sex-matched controls were given a 50-g oral glucose tolerance test (GTT). Ten years later the test was repeated in 382 cases. Of the original group, 126 had died and a similar number refused the second test. The original GTT results were classed as normal or as showing GTT diabetes, lag storage, renal glycosuria, or miscellaneous abnormalities. Most of those who converted to florid diabetes came from the GTT diabetes group, all the remainder having shown another minor degree of abnormality in the test; 23% with GTT diabetes, however, remained unchanged, while 32% returned to normal or had only minor anomalies. Of the original lag-storage group 57% remained unchanged or became normal, though 24% had converted to a diabetic abnormality. Renal glycosuria was an innocent peculiarity. The various miscellaneous abnormalities tended to change and showed an excessive conversion to diabetes. There was no accelerating trend towards diabetes in the second five years of follow-up. Those who developed florid diabetes showed an excess mortality comparable to that of clinical diabetics in general. Those who remained normal had the lowest mortality, while those with minor abnormalities occupied an intermediate position.
在1960 - 1961年的一项糖尿病调查中，对来自全体就诊人群的808名患者进行了50克口服葡萄糖耐量试验（GTT），这些患者要么有糖尿，要么作为年龄和性别匹配的对照。十年后，对382例患者重复进行了该试验。在最初的组中，126人已经死亡，另有相近数量的人拒绝参加第二次试验。最初的GTT结果被分类为正常或显示为GTT糖尿病、延迟储存、肾性糖尿或其他异常。大多数转变为显性糖尿病的人来自GTT糖尿病组，其余所有人在试验中都显示出另一种轻微程度的异常；然而，GTT糖尿病组中有23%的人保持不变，而32%的人恢复正常或仅有轻微异常。在最初的延迟储存组中，57%的人保持不变或恢复正常，尽管有24%的人转变为糖尿病异常。肾性糖尿是一种无害的特殊情况。各种其他异常往往会发生变化，并且显示出向糖尿病过度转变的情况。在随访的第二个五年中，没有向糖尿病加速发展的趋势。那些发展为显性糖尿病的人显示出与一般临床糖尿病患者相当的过高死亡率。那些保持正常的人死亡率最低，而那些有轻微异常的人处于中间位置。
