Jarrett R J, Keen H, Fuller J H, McCartney M
Diabetologia. 1979 Jan;16(1):25-30. doi: 10.1007/BF00423146.
Two hundred and four men with impaired glucose tolerance (borderline diabetes) discovered in a screening examination have been observed for five years and repeated tests of glucose tolerance performed. By pre-determined criteria 27 men 'worsened to diabetes' and this metabolic deterioration was not significantly influenced by treatment with carbohydrate restriction with or without a daily dose of 50 mg phenformin. Of the baseline variables measured prior to treatment allocation only the blood glucose values were significantly predictive of ultimate worsening to diabetes.
在一次筛查中发现的204名糖耐量受损（临界糖尿病）男性接受了为期五年的观察，并进行了重复的糖耐量测试。根据预先确定的标准，27名男性“病情恶化为糖尿病”，这种代谢恶化并未受到碳水化合物限制治疗（无论是否每日服用50毫克苯乙双胍）的显著影响。在治疗分配前测量的基线变量中，只有血糖值能显著预测最终恶化为糖尿病的情况。
