Buechner S A, Wernli M, Harr T, Hahn S, Itin P, Erb P
Department of Dermatology, University of Basel, Kantonsspital, Petersgraben 4, CH4031 Basel, Switzerland.
J Clin Invest. 1997 Dec 1;100(11):2691-6. doi: 10.1172/JCI119814.
Basal cell carcinoma (BCC) is the most common skin cancer in humans, and although metastasis rarely occurs, the tumor cells are nevertheless able to invade and destroy the surrounding tissue. Intralesional injection of IFN-alpha has been found to be highly effective in inducing BCC regression by an unknown mechanism. We show that in untreated patients, BCC cells express CD95 ligand, but not the receptor, which may allow tumor expansion by averting the attack of activated CD95 receptor-positive lymphoid effector cells. The CD95 ligand of BCC cells is functional as CD95-positive cells incubated on BCC cryosections become apoptotic and are lysed. In IFN-alpha-treated patients BCC cells express not only CD95 ligand but also CD95 receptor, whereas the peritumoral infiltrate that mainly consists of CD4+ T cells predominantly contains CD95 receptor and only few CD95 ligand-positive cells. Thus, in treated patients BCC most likely regresses by committing suicide through apoptosis induction via CD95 receptor-CD95 ligand interaction.
基底细胞癌（BCC）是人类最常见的皮肤癌，虽然很少发生转移，但肿瘤细胞仍能够侵袭并破坏周围组织。已发现病灶内注射α干扰素通过未知机制在诱导BCC消退方面非常有效。我们发现，在未经治疗的患者中，BCC细胞表达CD95配体，但不表达受体，这可能通过避免活化的CD95受体阳性淋巴效应细胞的攻击而使肿瘤得以扩展。BCC细胞的CD95配体具有功能，因为在BCC冰冻切片上孵育的CD95阳性细胞会发生凋亡并被裂解。在接受α干扰素治疗的患者中，BCC细胞不仅表达CD95配体，还表达CD95受体，而主要由CD4 + T细胞组成的肿瘤周围浸润主要含有CD95受体，只有少数CD95配体阳性细胞。因此，在接受治疗的患者中，BCC很可能通过CD95受体 - CD95配体相互作用诱导凋亡而自杀式死亡，从而发生消退。
