Wang S E, Ritchie M J, Atkinson B F
Department of Pathology, Newport Hospital, Rhode Island 02840, USA.
Acta Cytol. 1997 Nov-Dec;41(6):1690-6. doi: 10.1159/000333169.
To determine the false negative fraction (FNF) at a small community hospital and its relation to the discovery of a significant error.
All cervical cytologic smears (6,889) initially interpreted over a one-year period (1992) as "normal" or "near normal" were retrospectively rescreened and interpreted by outside institutions, without knowledge of the initial interpretation, to calculate yearly and quarterly FNFs.
The overall FNF for 1992 was 12.3% and was 19.1%, 22.2%, 3.8% and 6.1% per successive quarters in 1992. A significant error was discovered at the start of the third quarter that subsequently received both local and national media attention.
This study gives further proof that the FNF can be reduced to < 5% by motivated cytotechnologist/ pathologist teams, although it may not be possible to maintain this low an FNF.
确定一家小型社区医院的假阴性率（FNF）及其与重大错误发现之间的关系。
对1992年一年内最初被解读为“正常”或“接近正常”的所有宫颈细胞学涂片（6889份）进行回顾性重新筛查，并由外部机构在不知道初始解读结果的情况下进行解读，以计算年度和季度假阴性率。
1992年的总体假阴性率为12.3%，1992年随后连续几个季度分别为19.1%、22.2%、3.8%和6.1%。在第三季度开始时发现了一个重大错误，该错误随后受到了当地和全国媒体的关注。
本研究进一步证明，积极主动的细胞技术人员/病理学家团队可以将假阴性率降低至<5%，尽管可能无法一直保持如此低的假阴性率。
