Bourtros A R, Hoyt J L
Crit Care Med. 1976 May-Jun;4(3):144-7. doi: 10.1097/00003246-197605000-00003.
Manifestations of carbon monoxide poisoning are mostly attributable to acute hypoxic insult. In the absence of immediately available hyperbaric oxygen chamber, 100% oxygen should be delivered to the patient until carboxyhemoglobin levels in the blood are less than 5%. Presence of abnormal motor activity or prolonged abnormal consciousness are indications for proceeding with hypothermia and mechanical ventilation. Reversal of these manifestations was achieved in 3 reported cases though induction of hypothermia was delayed for as long as 24 hours. However, no beneficial effects were obtained in a fourth patient who did not receive hypothermia until 5 days after exposure. The duration of hypothermia varied between 60-70 hours in patients who showed near-complete recovery.
一氧化碳中毒的表现大多归因于急性缺氧损伤。在没有立即可用的高压氧舱的情况下，应向患者输送100%的氧气，直到血液中的碳氧血红蛋白水平低于5%。存在异常运动活动或长时间意识异常是进行低温治疗和机械通气的指征。在3例报告的病例中，尽管低温诱导延迟长达24小时，但这些表现仍得以逆转。然而，第四例患者在接触后5天才接受低温治疗，未获得有益效果。在显示近乎完全康复的患者中，低温治疗的持续时间在60至70小时之间。
