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白藜芦醇3 - O - β - D - 吡喃葡萄糖苷及相关化合物的分离、合成与抗血小板聚集活性

Isolation, synthesis, and antiplatelet aggregation activity of resveratrol 3-O-beta-D-glucopyranoside and related compounds.

作者信息

Orsini F, Pelizzoni F, Verotta L, Aburjai T, Rogers C B

机构信息

Dipartimento di Chimica Organica e Industriale, Università degli Studi, Milano, Italy.

出版信息

J Nat Prod. 1997 Nov;60(11):1082-7. doi: 10.1021/np970069t.

DOI:10.1021/np970069t
PMID:9392877
Abstract

Resveratrol 3-O-beta-D-glucopyranoside (1) has been isolated from the seeds of Erythrophleum lasianthum (Caesalpinioidae, Leguminosae), a South African plant used in traditional medicine, and has shown antiplatelet aggregation activity. The synthesis of 1, related hydroxystilbenes, and their glucosides has been undertaken to provide larger quantities, for further biological evaluation, and has been accomplished via Wittig reactions followed by glucosylation under phase transfer catalysis.

摘要

白藜芦醇3 - O - β - D - 吡喃葡萄糖苷(1)是从南非一种用于传统医学的植物——毛叶 Erythrophleum lasianthum(苏木科,豆科)的种子中分离得到的,并且已显示出抗血小板聚集活性。为了获得更大量的该化合物用于进一步的生物学评估,已开展了1及其相关羟基芪及其糖苷的合成研究,该合成是通过维蒂希反应,随后在相转移催化下进行糖基化反应来完成的。

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