Setzen G, Williams E F
Division of Otolaryngology-Head and Neck Surgery, Albany Medical Center, N.Y., USA.
Plast Reconstr Surg. 1997 Dec;100(7):1788-95. doi: 10.1097/00006534-199712000-00023.
We compared the tissue response to a nonabsorbable monofilamented suture made of expanded polytetrafluoroethylene (ePTFE), which has recently been introduced for use in plastic surgery, with the response to 10 other commercially available absorbable sutures and nonabsorbable monofilamented and multifilamented sutures. The sutures were used to secure a patch of ePTFE implanted in the dorsum of adult New Zealand White rabbits. At 30, 60, and 120 days after implantation, the tissue response to the sutures was assessed with respect to the number of foreign-body giant cells present, the thickness of the fibrous capsule that developed, and the general inflammatory response (n = 4 for each suture for each time period). Analysis of variance revealed that specific suture type was significantly associated with foreign-body giant cell count and fibrous capsule thickness. Tevdek had a significantly higher value for mean number of foreign-body giant cells. Silk and Tevdek had significantly thicker fibrous capsules, and ePTFE suture had a significantly thinner capsule. Absorbable sutures and nonabsorbable multifilamented sutures evoked a more extensive tissue response than monofilamented sutures; the differences between nonabsorbable monofilamented and nonabsorbable multifilamented sutures were significant for capsule thickness. In general, suture made of ePTFE produced a minimal tissue response. It should be a good choice for use in facial plastic surgery, in which excellent functional and aesthetic results are critical.
我们将一种由膨体聚四氟乙烯（ePTFE）制成的不可吸收单丝缝线（最近已引入整形外科使用）与其他10种市售可吸收缝线、不可吸收单丝缝线和多丝缝线的组织反应进行了比较。这些缝线用于固定植入成年新西兰白兔背部的一块ePTFE补片。在植入后30天、60天和120天，根据存在的异物巨细胞数量、形成的纤维囊厚度以及一般炎症反应，评估缝线的组织反应（每个时间段每种缝线n = 4）。方差分析显示，特定的缝线类型与异物巨细胞计数和纤维囊厚度显著相关。Tevdek的异物巨细胞平均数量值显著更高。丝线和Tevdek的纤维囊显著更厚，而ePTFE缝线的纤维囊显著更薄。可吸收缝线和不可吸收多丝缝线比单丝缝线引起更广泛的组织反应；不可吸收单丝缝线和不可吸收多丝缝线在囊厚度方面的差异显著。总体而言，ePTFE制成的缝线产生的组织反应最小。它应该是面部整形手术的一个好选择，在面部整形手术中，出色的功能和美学效果至关重要。
