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手术及激光消融在食管癌治疗中的作用。

The role of surgery and laser ablation in oesophageal carcinoma.

作者信息

Mulligan E D, O'Riordain M G, Duggan M, Crowe J, Lennon J, MacMathuna P, Fitzpatrick J M, Gorey T F

机构信息

Department of Surgery, Mater Misericordiae Hospital, Dublin.

出版信息

Ir J Med Sci. 1997 Oct-Dec;166(4):203-5. doi: 10.1007/BF02944233.

Abstract

Between January 1990 and December 1994 oesophagectomy was carried out in 42 patients and comparison made with 38 who had palliative laser therapy. Apart from six patients referred after being unresectable at surgical exploration there were no agreed selection criteria, although the laser patients were in general older (mean 64 V 73 year) with a higher proportion of cardiorespiratory co-morbidity (14 per cent V 18 per cent). Lateral margins were involved in 14 per cent of known palliative resections with 50 per cent having positive nodes. The mean operating time was three hours and two chest drains inserted electively were removed after 3.6 days with mean drainage of 817 ml. The mean ICU stay was 5.4 days and 3 had radiological leaks; all but one settled conservatively. The 90 day mortality was 11.9 per cent for surgery and 34 per cent for laser patients. Twenty-three patients (61 per cent) required further courses of laser-therapy for benign anastomotic stenosis. Including the initial treatment of both groups 6.0 procedures per patient year were required in the laser groups compared with 1.1 for surgery. The 1, 2 and 3 year survival was 60 per cent, 31 per cent, 39 per cent for surgery compared with 24 per cent, 8 per cent, 3 per cent for laser--12 surgical patients are still alive and well at mean of 29 months (range 16-68). Surgery where possible with acceptable morbidity and mortality offers good palliation and long-term survival is possible; selection criteria for palliation only need to be defined.

摘要

1990年1月至1994年12月期间,对42例患者实施了食管切除术,并与38例接受姑息性激光治疗的患者进行了比较。除6例在手术探查时发现无法切除而转诊的患者外,没有一致的选择标准,尽管接受激光治疗的患者一般年龄较大(平均64岁对73岁),心肺合并症的比例较高(14%对18%)。已知的姑息性切除术中,14%的病例切缘受累,50%的病例有阳性淋巴结。平均手术时间为3小时,选择性插入的两根胸腔引流管在3.6天后拔除,平均引流量为817毫升。平均重症监护病房停留时间为5.4天,3例有放射性渗漏;除1例保守治疗外,其余均治愈。手术患者的90天死亡率为11.9%,激光治疗患者为34%。23例患者(61%)因良性吻合口狭窄需要进一步的激光治疗疗程。包括两组的初始治疗,激光治疗组每名患者每年需要6.0次治疗,而手术组为1.1次。手术组1年、2年和3年生存率分别为60%、31%、39%,激光治疗组分别为24%、8%、3%——12例手术患者在平均29个月(范围16 - 68个月)时仍存活且状况良好。在可能的情况下,手术在可接受的发病率和死亡率情况下可提供良好的姑息治疗,并且有可能实现长期生存;仅姑息治疗的选择标准需要明确。

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