Lodi R, Montagna P, Soriani S, Iotti S, Arnaldi C, Cortelli P, Pierangeli G, Patuelli A, Zaniol P, Barbiroli B
Cattedra di Biochimica Clinica, Dipartimento di Medicina Clinica e Biotecnologia Applicata D Campanacci, Universitá di Bologna, Italy.
Pediatr Res. 1997 Dec;42(6):866-71. doi: 10.1203/00006450-199712000-00024.
We used phosphorus magnetic resonance spectroscopy (31P MRS) to investigate in vivo the brain and skeletal muscle energy metabolism of 15 children with migraine with aura in interictal periods. Brain 31P MRS disclosed low phosphocreatine and high inorganic phosphate contents, and high intracellular pH in all patients. Calculated [ADP] and the relative rate of mitochondrial oxidation were higher in the brain of patients than in control subjects, whereas the phosphorylation potential was lower. Brain intracellular free Mg2+ concentration was reduced by 25% in patients. Abnormal skeletal muscle mitochondrial respiration was also disclosed in 7 of 15 patients as shown by the slow rate of phosphocreatine postexercise recovery. The multisystem bioenergetic failure found in patients with juvenile migraine is comparable to that found in adults with different types of migraine.
我们采用磷磁共振波谱法（31P MRS）对15例发作间期有先兆偏头痛患儿的脑和骨骼肌能量代谢进行了体内研究。脑31P MRS显示，所有患者的磷酸肌酸含量低、无机磷含量高，且细胞内pH值高。计算得出的[ADP]和线粒体氧化相对速率在患者脑中高于对照组，而磷酸化电位较低。患者脑内细胞内游离Mg2+浓度降低了25%。15例患者中有7例骨骼肌线粒体呼吸异常，表现为运动后磷酸肌酸恢复速率缓慢。青少年偏头痛患者中发现的多系统生物能量衰竭与不同类型偏头痛的成年患者中发现的情况相当。
