无先兆偏头痛的31P磁共振波谱分析

31P-magnetic resonance spectroscopy in migraine without aura.

作者信息

Montagna P, Cortelli P, Monari L, Pierangeli G, Parchi P, Lodi R, Iotti S, Frassineti C, Zaniol P, Lugaresi E

机构信息

Institute of Neurology, Medical Pathology Institute D. Campanacci, University of Bologna, Italy.

出版信息

Neurology. 1994 Apr;44(4):666-9. doi: 10.1212/wnl.44.4.666.

DOI:10.1212/wnl.44.4.666

PMID:8164822

Abstract

We investigated 22 patients with migraine without aura, all drug-free and in headache-free periods, by means of 31P-magnetic resonance spectroscopy (MRS) of brain and muscle. Brain 31P-MRS showed significantly low phosphocreatine, increased adenosine diphosphate, and decreased phosphorylation potential. There was a slow rate of phosphocreatine recovery after exercise in the muscle of 12 of 22 patients. Energy metabolism is abnormal in migraine without aura, as previously demonstrated in patients with migraine stroke and migraine with aura.

摘要

我们通过对大脑和肌肉进行31P磁共振波谱（MRS）研究了22例无先兆偏头痛患者，所有患者均未服用药物且处于无头痛期。大脑31P-MRS显示磷酸肌酸显著降低、二磷酸腺苷增加以及磷酸化电位降低。22例患者中有12例患者的肌肉在运动后磷酸肌酸恢复速率缓慢。无先兆偏头痛患者的能量代谢异常，正如先前在偏头痛性卒中患者和有先兆偏头痛患者中所证实的那样。