Montagna P, Lodi R, Cortelli P, Pierangeli G, Iotti S, Cevoli S, Zaniol P, Barbiroli B
Institute of Clinical Neurology, University of Bologna, Italy.
Neurology. 1997 Jan;48(1):113-8. doi: 10.1212/wnl.48.1.113.
We performed in vivo MR spectroscopy phosphorus (31P-MRS) on the brain and skeletal muscles of 14 patients affected with cluster headache (CH). We examined patients in interictal periods, and also examined nine of them during the cluster period, although not during the attack. Brain 31P-MRS showed reduced phosphocreatine (PCr) levels, an increased ADP concentration (calculated from the creatine kinase equilibrium), a reduced phosphorylation potential, and a high relative rate of ATP biosynthesis (V/Vmax %). The inorganic phosphate (P(i)) content was increased during the cluster period. Ten of 13 patients also showed a slow rate of PCr recovery in muscle after the exercise. 31P-MRS in CH patients showed abnormalities of brain and skeletal muscle energy metabolism comparable with those seen in various types of migraine, thus leading us to suggest a similarity in biochemical pathogenic mechanisms between CH and migraine.
我们对14名丛集性头痛（CH）患者的大脑和骨骼肌进行了活体磷磁共振波谱分析（31P-MRS）。我们在发作间期对患者进行了检查，并且对其中9名患者在丛集期进行了检查，不过不是在发作时。大脑31P-MRS显示磷酸肌酸（PCr）水平降低、ADP浓度升高（根据肌酸激酶平衡计算得出）、磷酸化电位降低以及ATP生物合成的相对速率较高（V/Vmax%）。无机磷酸盐（P(i)）含量在丛集期增加。13名患者中有10名在运动后肌肉中PCr恢复速率也较慢。CH患者的31P-MRS显示大脑和骨骼肌能量代谢异常，与各种类型偏头痛中所见的异常情况相当，因此我们认为CH和偏头痛在生化致病机制上具有相似性。
