Lodi R, Kemp G J, Montagna P, Pierangeli G, Cortelli P, Iotti S, Radda G K, Barbiroli B
Dipartimento di Medicina Clinica e Biotecnologia Applicata D. Campanacci, Universita di Bologna, Italy.
J Neurol Sci. 1997 Feb 27;146(1):73-80. doi: 10.1016/s0022-510x(96)00287-0.
Phosphorus MR spectroscopy (31P-MRS) was used to quantify skeletal muscle bioenergetics and proton efflux in 63 patients with migraine (23 with migraine without aura, MwoA, 22 with migraine with aura, MwA, and 18 with prolonged aura or stroke, CM) and in 14 patients with cluster headache (CH), all in an attack-free period. At rest mitochondrial function was abnormal only in CM, as shown by a low phosphocreatine (PCr) concentration. At the end of a mixed glycolytic/aerobic exercise all three migraine groups showed a significantly smaller decrease of cytosolic pH compared to controls with a similar end-exercise PCr breakdown, while end-exercise pH was normal in cluster headache patients. The normal rate of proton efflux in all headache groups suggests that the reduced end-exercise acidification was due to a reduction of glycolytic flux in migraine patients. The maximum rate of mitochondrial ATP production (Qmax), calculated from the rate of post-exercise PCr recovery and the end-exercise [ADP], was low in cluster headache patients as well as in migraine patients except MwoA. In migraine the degree of the mitochondrial impairment, that apparently is associated with a reduced glycolytic flux, is related to the severity of the clinical phenotype.
采用磷磁共振波谱（31P-MRS）对63例偏头痛患者（23例无先兆偏头痛，22例有先兆偏头痛，18例有持续性先兆或卒中样偏头痛）以及14例丛集性头痛患者在发作间期进行骨骼肌生物能量学和质子外流的定量分析。静息状态下，仅持续性先兆或卒中样偏头痛患者的线粒体功能异常，表现为磷酸肌酸（PCr）浓度降低。在混合糖酵解/有氧运动结束时，与运动结束时PCr分解相似的对照组相比，所有三个偏头痛组的胞质pH值下降均显著较小，而丛集性头痛患者运动结束时的pH值正常。所有头痛组的质子外流率正常，提示偏头痛患者运动结束时酸化程度降低是由于糖酵解通量减少所致。根据运动后PCr恢复率和运动结束时[ADP]计算的线粒体ATP最大生成率（Qmax），除无先兆偏头痛患者外，丛集性头痛患者和偏头痛患者均较低。在偏头痛中，线粒体损伤程度显然与糖酵解通量降低有关，且与临床表型的严重程度相关。
