Barbiroli B, Montagna P, Cortelli P, Funicello R, Iotti S, Monari L, Pierangeli G, Zaniol P, Lugaresi E
Cattedra di Biochimica Clinica dell'Università di Bologna, Italy.
Neurology. 1992 Jun;42(6):1209-14. doi: 10.1212/wnl.42.6.1209.
We studied brain and muscle energy metabolism by phosphorus 31 magnetic resonance spectroscopy (31P-MRS) in 12 patients affected by migraine with aura (classic migraine) in interictal periods. Brain 31P-MRS disclosed a low phosphocreatine content in all patients, accompanied by high adenosine diphosphate concentration, a high percentage of V/Vmax (adenosine triphosphate), and a low phosphorylation potential--features showing an unstable state of metabolism in classic migraine. Abnormal muscle mitochondrial function, in the absence of clinical signs of muscle impairment, was present in nine of the 12 patients examined.
我们采用磷31磁共振波谱法（31P-MRS）对12例有先兆偏头痛（典型偏头痛）患者发作间期的脑和肌肉能量代谢进行了研究。脑31P-MRS显示，所有患者的磷酸肌酸含量均较低，同时伴有二磷酸腺苷浓度升高、三磷酸腺苷V/Vmax百分比升高以及磷酸化电位降低，这些特征表明典型偏头痛患者的代谢状态不稳定。在接受检查的12例患者中，有9例存在异常的肌肉线粒体功能，而此时并无肌肉损伤的临床体征。
