• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

肌醇脂质5-磷酸酶——交通信号与信号通路

Inositol lipid 5-phosphatases--traffic signals and signal traffic.

作者信息

Woscholski R, Parker P J

机构信息

Protein Phosphorylation Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, UK.

出版信息

Trends Biochem Sci. 1997 Nov;22(11):427-31. doi: 10.1016/s0968-0004(97)01120-1.

DOI:10.1016/s0968-0004(97)01120-1
PMID:9397684
Abstract

Several novel phosphoinositide 5-phosphatases have been identified and characterised, revealing a growing family of regulators of inositol lipid dependent processes. The features of these proteins, their likely partners and their involvement in signal transduction and membrane traffic is discussed.

摘要

几种新型磷酸肌醇5-磷酸酶已被鉴定和表征,这揭示了一个不断壮大的调节肌醇脂质依赖性过程的蛋白质家族。本文讨论了这些蛋白质的特性、它们可能的相互作用蛋白以及它们在信号转导和膜运输中的作用。

相似文献

1
Inositol lipid 5-phosphatases--traffic signals and signal traffic.肌醇脂质5-磷酸酶——交通信号与信号通路
Trends Biochem Sci. 1997 Nov;22(11):427-31. doi: 10.1016/s0968-0004(97)01120-1.
2
Inositol lipid phosphatases in membrane trafficking and human disease.膜转运和人类疾病中的肌醇脂质磷酸酶。
Biochem J. 2014 Jul 15;461(2):159-75. doi: 10.1042/BJ20140361.
3
Phosphoinositide phosphatases and disease.磷酸肌醇磷酸酶与疾病
J Lipid Res. 2009 Apr;50 Suppl(Suppl):S249-54. doi: 10.1194/jlr.R800072-JLR200. Epub 2008 Nov 11.
4
Inositol polyphosphate 5-phosphatases: lipid phosphatases with flair.肌醇多磷酸5-磷酸酶:独具特色的脂质磷酸酶。
IUBMB Life. 2002 Jan;53(1):25-36. doi: 10.1080/15216540210815.
5
Regulation of PtdIns(3,4,5)P3/Akt signalling by inositol polyphosphate 5-phosphatases.肌醇多磷酸5-磷酸酶对磷脂酰肌醇-3,4,5-三磷酸/蛋白激酶B信号通路的调控
Biochem Soc Trans. 2016 Feb;44(1):240-52. doi: 10.1042/BST20150214.
6
The structure and function of catalytic domains within inositol polyphosphate 5-phosphatases.肌醇多磷酸5-磷酸酶催化结构域的结构与功能
IUBMB Life. 2002 Jan;53(1):15-23. doi: 10.1080/15216540210814.
7
The inositol polyphosphate 5-phosphatases: traffic controllers, waistline watchers and tumour suppressors?肌醇多磷酸5-磷酸酶:交通管制员、腰围守护者和肿瘤抑制因子?
Biochem Soc Symp. 2007(74):161-81. doi: 10.1042/BSS0740161.
8
A new paradigm in phosphoinositide signaling? (Comment on DOI 10.1002/bies.201100195).磷脂酰肌醇信号传导的新范式?(评论DOI 10.1002/bies.201100195)
Bioessays. 2012 Aug;34(8):633. doi: 10.1002/bies.201200091.
9
Regulation of phosphoinositide signaling by the inositol polyphosphate 5-phosphatases.肌醇多磷酸5-磷酸酶对磷酸肌醇信号的调控
IUBMB Life. 2006 Aug;58(8):451-6. doi: 10.1080/15216540600871159.
10
The membrane and lipids as integral participants in signal transduction: lipid signal transduction for the non-lipid biochemist.膜和脂质作为信号转导的重要参与者:面向非脂质生物化学家的脂质信号转导
Adv Physiol Educ. 2007 Mar;31(1):5-16. doi: 10.1152/advan.00088.2006.

引用本文的文献

1
Development of mutation-selective LRRK2 kinase inhibitors as precision medicine for Parkinson's disease and other diseases for which carriers are at increased risk.开发突变选择性LRRK2激酶抑制剂作为帕金森病及其他携带者患病风险增加疾病的精准药物。
Front Neurol. 2022 Oct 26;13:1016040. doi: 10.3389/fneur.2022.1016040. eCollection 2022.
2
Phosphoinositide phosphatases in a network of signalling reactions.信号反应网络中的磷酸肌醇磷酸酶
Pflugers Arch. 2007 Oct;455(1):31-44. doi: 10.1007/s00424-007-0304-5. Epub 2007 Jun 29.
3
A novel mode of action for a microbial-derived immunotoxin: the cytolethal distending toxin subunit B exhibits phosphatidylinositol 3,4,5-triphosphate phosphatase activity.
一种微生物源免疫毒素的新型作用模式:细胞致死性扩张毒素B亚基具有磷脂酰肌醇3,4,5-三磷酸磷酸酶活性。
J Immunol. 2007 Apr 15;178(8):5099-108. doi: 10.4049/jimmunol.178.8.5099.
4
Platelet-derived growth factor-BB-mediated glycosaminoglycan synthesis is transduced through Akt.血小板衍生生长因子-BB介导的糖胺聚糖合成通过Akt转导。
Biochem J. 2002 Apr 1;363(Pt 1):19-28. doi: 10.1042/0264-6021:3630019.
5
SH2-containing inositol 5'-phosphatase SHIP2 associates with the p130(Cas) adapter protein and regulates cellular adhesion and spreading.含SH2结构域的肌醇5'-磷酸酶SHIP2与衔接蛋白p130(Cas)结合,并调节细胞黏附与铺展。
Mol Cell Biol. 2001 Feb;21(4):1416-28. doi: 10.1128/MCB.21.4.1416-1428.2001.
6
Sac phosphatase domain proteins.液泡磷酸酶结构域蛋白
Biochem J. 2000 Sep 1;350 Pt 2(Pt 2):337-52.
7
The PI3K-PDK1 connection: more than just a road to PKB.磷脂酰肌醇-3激酶与丙酮酸脱氢酶激酶1的联系:不仅仅是通往蛋白激酶B的一条途径。
Biochem J. 2000 Mar 15;346 Pt 3(Pt 3):561-76.
8
Characterization of a germline mosaicism in families with Lowe syndrome, and identification of seven novel mutations in the OCRL1 gene.Lowe综合征家庭中生殖系嵌合体的特征分析以及OCRL1基因七个新突变的鉴定。
Am J Hum Genet. 1999 Jul;65(1):68-76. doi: 10.1086/302443.
9
The Croonian Lecture 1998. Identification of a protein kinase cascade of major importance in insulin signal transduction.1998年克罗尼安讲座。鉴定胰岛素信号转导中至关重要的蛋白激酶级联反应。
Philos Trans R Soc Lond B Biol Sci. 1999 Feb 28;354(1382):485-95. doi: 10.1098/rstb.1999.0399.
10
Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1.磷脂酰肌醇-3,4,5-三磷酸在调节3-磷酸肌醇依赖性蛋白激酶-1的活性和定位中的作用
Biochem J. 1999 Feb 1;337 ( Pt 3)(Pt 3):575-83.