静脉注射4-甲基吡唑治疗甲醇中毒

Treatment of methanol poisoning with intravenous 4-methylpyrazole.

作者信息

Burns M J, Graudins A, Aaron C K, McMartin K, Brent J

机构信息

Department of Emergency Medicine, University of Massachusetts Medical Center, Worcester, USA.

出版信息

Ann Emerg Med. 1997 Dec;30(6):829-32. doi: 10.1016/s0196-0644(97)70060-x.

DOI:10.1016/s0196-0644(97)70060-x

PMID:9398786

Abstract

Treatment of human methanol poisoning with the alcohol dehydrogenase inhibitor, 4-methylpyrazole (fomepizole), has not been previously described. We report the clinical and toxicokinetic data of a patient with methanol poisoning who was treated with fomepizole. Formic acid levels remained undetectable during fomepizole treatment, the toxic effects of methanol were prevented, and the patient made a full recovery.

摘要

此前尚未描述过使用乙醇脱氢酶抑制剂4-甲基吡唑（甲吡唑）治疗人类甲醇中毒的情况。我们报告了一名接受甲吡唑治疗的甲醇中毒患者的临床和毒代动力学数据。在甲吡唑治疗期间，甲酸水平一直未检测到，甲醇的毒性作用得到了预防，患者完全康复。