Liguori R, Cordivari C, Lugaresi E, Montagna P
Institute of Neurology, University of Bologna, Italy.
Mov Disord. 1997 Nov;12(6):1060-3. doi: 10.1002/mds.870120636.
We studied the effect of botulinum toxin A (BTA) on painful muscular spasms and rigidity in two bedridden patients with clinical, electrophysiologic, and immunologic evidence of stiff-person syndrome. We injected BTA or saline solution into several limb muscles with both the rater and patient blinded to the order of the injections. A physician, unaware of the treatment order, used an objective rating scale for rigidity and spasm frequency scale and independently assessed the treatment results. BTA administration significantly reduced rigidity and stopped the spasms in all limbs. Following BTA injection on one side, the spasm frequency decreased bilaterally possibly because of the spread of hematogenous toxin.
我们研究了A型肉毒杆菌毒素（BTA）对两名卧床患者疼痛性肌肉痉挛和僵硬的影响，这两名患者具有僵人综合征的临床、电生理和免疫学证据。我们将BTA或生理盐水注射到患者的几块肢体肌肉中，评估者和患者均不知注射顺序。一名不知治疗顺序的医生使用了僵硬客观评分量表和痉挛频率量表，并独立评估治疗结果。注射BTA后，患者四肢的僵硬程度显著降低，痉挛停止。在一侧注射BTA后，两侧的痉挛频率均下降，这可能是由于血源性毒素的扩散所致。
