Lobo Marcelo Evangelista, Araújo Marx Lincoln Barros, Tomaz Carlos Alberto Bezerra, Allam Nasser
Department of Neurology, Hospital Universitário de Brasília, Brasilia, Brazil.
BMJ Case Rep. 2010 Dec 13;2010:bcr0520103021. doi: 10.1136/bcr.05.2010.3021.
Stiff-person syndrome (SPS) is a rare neurological condition consisting of progressive and fluctuating rigidity of the axial muscles combined with painful spasms. The pathophysiology of SPS is not fully understood, but there seems to be an autoimmune component. The use of rituximab, a chimeric monoclonal antibody targeting CD20 protein in the surface of mature B cells, for the treatment of SPS is a recent therapeutical approach showing promising results. The authors present a case report of a 41-year-old female patient diagnosed with SPS who was treated with rituximab in a public hospital in Brasília, Brazil, showing a good and safe response to the treatment so far. Our data go along with some recent articles published in the literature.
僵人综合征（SPS）是一种罕见的神经系统疾病，表现为轴向肌肉进行性和波动性僵硬，并伴有疼痛性痉挛。SPS的病理生理学尚未完全明确，但似乎存在自身免疫成分。利妥昔单抗是一种靶向成熟B细胞表面CD20蛋白的嵌合单克隆抗体，将其用于治疗SPS是一种近期的治疗方法，已显示出有前景的结果。作者报告了一例41岁女性SPS患者的病例，该患者在巴西巴西利亚的一家公立医院接受了利妥昔单抗治疗，目前显示出对治疗良好且安全的反应。我们的数据与文献中最近发表的一些文章一致。
