Kugler J D, Danford D A, Houston K, Felix G
Joint Division of Pediatric Cardiology, UN Medical Center/Creighton University, Omaha, Nebraska 68114, USA.
Am J Cardiol. 1997 Dec 1;80(11):1438-43. doi: 10.1016/s0002-9149(97)00736-4.
Since 1990, management options available for children with paroxysmal supraventricular tachycardia (PSVT) have included radiofrequency catheter ablation (RCA). To determine the efficacy and safety of the procedure and to maintain a database for long-term follow-up, the Pediatric Electrophysiology Society began a Pediatric RCA Registry on January 1, 1991, to which 46 centers have submitted data from 4,135 total children and adolescents (patient age 0.1 to 20.9 years) who underwent 4,651 RCAs (through September 15, 1996). Of the 88% with a structurally normal heart, PSVT mechanisms (n = 4,030) included 3,110 accessory pathways and 920 atrioventricular node reentry tachycardia (AVNRT) during 3,653 procedures for 3,277 patients. During the 7 years of the Registry, analysis of indications for the procedure has shown a gradual shift. During the first year of the Registry for this PSVT group, "medically refractory tachycardia" was listed as the indication for 44% and "patient choice" was listed as 33%, compared with 29% and 58%, respectively, for the years 1995 to 1996 (p <0.005). Registry results were: 90% immediate success for accessory pathways (95% for left lateral; 87% for septal; 86% for right free wall) and 96% for AVNRT; mean fluoroscopy time 47.6 +/- 40 SD minutes; procedure time 257 +/- 157 SD minutes; major complication rate at the time of the procedure 3.2%. Procedure-related deaths included 1 immediate and 3 at 2, 12 and 68 weeks after the procedure (2 were infants). Follow-up revealed 77% and 71% freedom from recurrence at 3 years for accessory pathways AVNRT, respectively, and rare (<1%) detection of additional complications. RCA has evolved into a standard management option for PSVT in children with a structurally normal heart. RCA for children and adolescents should be recommended after consideration of the procedural risk/benefit compared with that of other management options, the natural history, and individual tolerance/symptoms related to PSVT.
自1990年以来,阵发性室上性心动过速(PSVT)患儿可选择的治疗方法包括射频导管消融术(RCA)。为了确定该手术的疗效和安全性,并建立一个长期随访数据库,小儿电生理学会于1991年1月1日启动了小儿RCA登记处,46个中心提交了4135名儿童和青少年(患者年龄0.1至20.9岁)的数据,这些患者共接受了4651次RCA手术(截至1996年9月15日)。在心脏结构正常的88%的患者中,PSVT机制(n = 4030)包括3110条旁路和920例房室结折返性心动过速(AVNRT),这是在3277例患者的3653次手术中发现的。在登记处的7年期间,对该手术适应证的分析显示出逐渐的转变。在该PSVT组登记处的第一年,“药物难治性心动过速”被列为适应证的占44%,“患者选择”占33%,而在1995年至1996年,这两个比例分别为29%和58%(p <0.005)。登记处的结果为:旁路的即刻成功率为90%(左侧旁路为95%;间隔旁路为87%;右侧游离壁旁路为86%),AVNRT为96%;平均透视时间为47.6±40标准差分钟;手术时间为257±157标准差分钟;手术时的主要并发症发生率为3.2%。与手术相关的死亡包括1例术中死亡和3例分别在术后2周、12周和68周死亡(2例为婴儿)。随访显示,旁路和AVNRT在3年时的复发率分别为77%和71%,且很少(<1%)发现其他并发症。对于心脏结构正常的PSVT患儿,RCA已发展成为一种标准的治疗选择。在考虑与其他治疗选择相比的手术风险/获益、自然病史以及与PSVT相关的个体耐受性/症状后,应推荐对儿童和青少年进行RCA治疗。