蛋白质结构-序列比对与家族图谱的HSSP数据库。
The HSSP database of protein structure-sequence alignments and family profiles.
作者信息
Dodge C, Schneider R, Sander C
机构信息
European Bioinformatics Institute, EMBL-EBI, Genome Campus, Cambridge CB10 1SD, UK.
出版信息
Nucleic Acids Res. 1998 Jan 1;26(1):313-5. doi: 10.1093/nar/26.1.313.
Abstract
HSSP (http: //www.sander.embl-ebi.ac.uk/hssp/) is a derived database merging structure (3-D) and sequence (1-D) information. For each protein of known 3D structure from the Protein Data Bank (PDB), we provide a multiple sequence alignment of putative homologues and a sequence profile characteristic of the protein family, centered on the known structure. The list of homologues is the result of an iterative database search in SWISS-PROT using a position-weighted dynamic programming method for sequence profile alignment (MaxHom). The database is updated frequently. The listed putative homologues are very likely to have the same 3D structure as the PDB protein to which they have been aligned. As a result, the database not only provides aligned sequence families, but also implies secondary and tertiary structures covering 33% of all sequences in SWISS-PROT.
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本文引用的文献
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