Blahová J, Králiková K, Krcméry V, Torsová V
Institute of Preventive and Clinical medicine, Limbová, Bratislava, Slovak Republic.
Diagn Microbiol Infect Dis. 1997 Nov;29(3):129-32. doi: 10.1016/s0732-8893(97)81801-9.
Stenotrophomonas maltophilia (298/85) was isolated from the extensively inflamed conjunctiva of a neonate in a regional hospital in Ostrava, Czech Republic. It was resistant to all available antibiotics except cefepime and trimethoprim. The donor S. maltophilia strain 298/85 transferred carbenicillin and cephaloridine resistance determinants to recipient strains of Escherichia coli K-12 3110 rif+ and Proteus mirabilis P-38 rif+. All transconjugant colonies were co-resistant also to kanamycin, cefotaxime, and aztreonam. Active hydrolysis of imipenem in the original strain was inhibited by ethylene diamine tetra-acetic acid, and hydrolysis of cefotaxime and aztreonam in the original strain and in the E. coli K-12 transconjugant was inhibited by clavulanate. In contrast, ceftazidime was hydrolyzed by the original strain and was not inhibited by clavulanate, indicating a different character of the resistance to cefotaxime or aztreonam and ceftazidime.
嗜麦芽窄食单胞菌（298/85）从捷克共和国俄斯特拉发一家地区医院一名新生儿广泛发炎的结膜中分离得到。它对除头孢吡肟和甲氧苄啶外的所有可用抗生素均耐药。供体嗜麦芽窄食单胞菌菌株298/85将羧苄青霉素和头孢菌素耐药决定簇转移至大肠杆菌K-12 3110 rif+和奇异变形杆菌P-38 rif+的受体菌株。所有接合子菌落对卡那霉素、头孢噻肟和氨曲南也均耐药。原始菌株中对亚胺培南的活性水解被乙二胺四乙酸抑制，原始菌株以及大肠杆菌K-12接合子中对头孢噻肟和氨曲南的水解被克拉维酸抑制。相比之下，头孢他啶被原始菌株水解且不受克拉维酸抑制，这表明对头孢噻肟或氨曲南以及头孢他啶的耐药特性不同。
