癌症患者人类精子中的肌酸激酶水平和脂质过氧化率。
Creatine kinase level and lipid peroxidation rate in human spermatozoa from patients with cancer.
作者信息
Sidhu R S, Wang Y, Agarwal A
机构信息
Department of Urology, Cleveland Clinic Foundation, Ohio 44195, USA.
出版信息
J Assist Reprod Genet. 1997 Oct;14(9):538-42. doi: 10.1023/a:1021183528047.
PURPOSE
The present study assessed whether the poor semen quality in patients with cancer results from the inhibition of sperm maturation as indicated by creatine kinase or from increased oxidative stress as assessed by lipid peroxidation of the sperm membrane.
METHODS
Cryopreserved semen specimens from patients with testicular (n = 10) and nontesticular (n = 12) cancer and normal healthy donors (n = 14) were analyzed for lipid peroxidation and creatine kinase levels.
RESULTS
The levels of creatine kinase and malonaldehyde did not differ among testicular or nontesticular patients with cancer or normal healthy donors.
CONCLUSIONS
Poor semen quality in testicular and nontesticular patients with cancer is not related to creatine kinase or lipid peroxidation levels; it may be related to other factors.
目的
本研究评估癌症患者精液质量差是源于肌酸激酶所表明的精子成熟抑制，还是源于精子膜脂质过氧化所评估的氧化应激增加。
方法
分析来自睾丸癌患者（n = 10）、非睾丸癌患者（n = 12）和正常健康供者（n = 14）的冷冻保存精液标本的脂质过氧化和肌酸激酶水平。
结果
睾丸癌或非睾丸癌患者与正常健康供者之间，肌酸激酶和丙二醛水平并无差异。
结论
睾丸癌和非睾丸癌患者精液质量差与肌酸激酶或脂质过氧化水平无关；可能与其他因素有关。
Zotero 插件