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J Assist Reprod Genet. 1997 Oct;14(9):538-42. doi: 10.1023/a:1021183528047.
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Editorial Comment: Antioxidant enzyme profile and lipid peroxidation products in semen samples of testicular germ cell tumor patients submitted to orchiectomy.编者按：接受睾丸切除术的睾丸生殖细胞肿瘤患者精液样本中的抗氧化酶谱和脂质过氧化产物。
Int Braz J Urol. 2017 Jul-Aug;43(4):652-654. doi: 10.1590/S1677-5538.IBJU.2016.0323.1.
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Sperm creatine kinase activity in normospermic and oligozospermic Hungarian men.匈牙利正常精子数和少精子症男性的精子肌酸激酶活性
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本文引用的文献

1
Time course of hydrogen peroxide induced changes in the lipid peroxidation of human sperm membranes.
Adv Contracept Deliv Syst. 1992;8(1-2):144-50.
2
Value of clinical diagnosis in predicting the quality of cryopreserved sperm from cancer patients.临床诊断对预测癌症患者冷冻精子质量的价值。
J Urol. 1996 Mar;155(3):934-8.
3
Fertility in the testicular cancer patient.睾丸癌患者的生育能力。
World J Urol. 1993;11(2):70-5. doi: 10.1007/BF00182032.
4
Effect of cryoprotective additives and cryopreservation protocol on sperm membrane lipid peroxidation and recovery of motile human sperm.冷冻保护添加剂和冷冻保存方案对人精子膜脂质过氧化及活动精子复苏的影响。
J Androl. 1993 Nov-Dec;14(6):472-8.
5
Effect of sodium nitroprusside on sperm motility, viability, and lipid peroxidation.硝普钠对精子活力、存活率及脂质过氧化的影响。
Fertil Steril. 1994 Jun;61(6):1117-22. doi: 10.1016/s0015-0282(16)56766-1.
6
Pathophysiology of human spermatozoa.
Curr Opin Obstet Gynecol. 1994 Apr;6(2):128-35.
7
Correlation between the rate of lipid peroxidation and cellular maturity as measured by creatine kinase activity in human spermatozoa.
J Androl. 1994 Jan-Feb;15(1):71-7.
8
Relationships between biochemical markers for residual sperm cytoplasm, reactive oxygen species generation, and the presence of leukocytes and precursor germ cells in human sperm suspensions.
Mol Reprod Dev. 1994 Nov;39(3):268-79. doi: 10.1002/mrd.1080390304.
9
Relevance of acrosome function in the evaluation of semen in vitro fertilizing ability.顶体功能在评估精液体外受精能力中的相关性。
Fertil Steril. 1995 Mar;63(3):598-603. doi: 10.1016/s0015-0282(16)57432-9.
10
Seminal fluid analysis and sperm function testing.精液分析和精子功能测试。
Endocrinol Metab Clin North Am. 1994 Dec;23(4):725-48.

癌症患者人类精子中的肌酸激酶水平和脂质过氧化率。

Creatine kinase level and lipid peroxidation rate in human spermatozoa from patients with cancer.

作者信息

Sidhu R S, Wang Y, Agarwal A

机构信息

Department of Urology, Cleveland Clinic Foundation, Ohio 44195, USA.

出版信息

J Assist Reprod Genet. 1997 Oct;14(9):538-42. doi: 10.1023/a:1021183528047.

DOI:10.1023/a:1021183528047
PMID:9401873
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3454844/
Abstract

PURPOSE

The present study assessed whether the poor semen quality in patients with cancer results from the inhibition of sperm maturation as indicated by creatine kinase or from increased oxidative stress as assessed by lipid peroxidation of the sperm membrane.

METHODS

Cryopreserved semen specimens from patients with testicular (n = 10) and nontesticular (n = 12) cancer and normal healthy donors (n = 14) were analyzed for lipid peroxidation and creatine kinase levels.

RESULTS

The levels of creatine kinase and malonaldehyde did not differ among testicular or nontesticular patients with cancer or normal healthy donors.

CONCLUSIONS

Poor semen quality in testicular and nontesticular patients with cancer is not related to creatine kinase or lipid peroxidation levels; it may be related to other factors.

摘要

目的

本研究评估癌症患者精液质量差是源于肌酸激酶所表明的精子成熟抑制，还是源于精子膜脂质过氧化所评估的氧化应激增加。

方法

分析来自睾丸癌患者（n = 10）、非睾丸癌患者（n = 12）和正常健康供者（n = 14）的冷冻保存精液标本的脂质过氧化和肌酸激酶水平。

结果

睾丸癌或非睾丸癌患者与正常健康供者之间，肌酸激酶和丙二醛水平并无差异。

结论

睾丸癌和非睾丸癌患者精液质量差与肌酸激酶或脂质过氧化水平无关；可能与其他因素有关。