Bazin R, Lavau M
Digestion. 1979;19(6):386-91. doi: 10.1159/000198399.
In man and in rat, the diabetic state is associated with diseases of exocrine pancreatic function. In this work, streptozotocin diabetes was shown to lead to a 95% decrease in the amylase to lipase ratio in rats. Diabetes was reversed by either pancreas transplantation or insulin treatment. Transplantation of neonatal pancreases was successful in reversing the diabetic-induced alterations of exocrine pancreatic function. To assess whether insulin acts directly on the exocrine pancreas, or through the enhancement of glucose utilization, animals were fed either a low-fat diet or a high-fat diet during insulin treatment; this latter diet is well known to impair insulin's effect on glucose metabolism. When diabetic rats were fed a low-fat diet, insulin treatment was able to correct the hyperketonemia and to reverse the amylase to lipase ratio to the prediabetes level. In contrast, the insulin treatment failed to restore the amylase to lipase ratio when the diabetic rats were fed the high-fat diet. Despite insulin treatment, the hyperketonemia worsened implying that glucose utilization remained low as would be expected on high-fat diet. The dependence of the insulin effect upon diet composition demonstrates that the rate of glucose metabolism is the primary factor in the regulation of amylase to lipase ratio.
在人类和大鼠中，糖尿病状态与胰腺外分泌功能疾病相关。在这项研究中，链脲佐菌素诱导的糖尿病导致大鼠淀粉酶与脂肪酶的比例下降了95%。胰腺移植或胰岛素治疗可逆转糖尿病状态。新生胰腺移植成功逆转了糖尿病引起的胰腺外分泌功能改变。为了评估胰岛素是直接作用于胰腺外分泌腺，还是通过增强葡萄糖利用来发挥作用，在胰岛素治疗期间，给动物喂食低脂饮食或高脂饮食；众所周知，后者这种饮食会削弱胰岛素对葡萄糖代谢的作用。当给糖尿病大鼠喂食低脂饮食时，胰岛素治疗能够纠正高酮血症，并使淀粉酶与脂肪酶的比例恢复到糖尿病前期水平。相比之下，当给糖尿病大鼠喂食高脂饮食时，胰岛素治疗未能恢复淀粉酶与脂肪酶的比例。尽管进行了胰岛素治疗，但高酮血症仍恶化，这意味着如高脂饮食所预期的那样，葡萄糖利用率仍然很低。胰岛素作用对饮食组成的依赖性表明，葡萄糖代谢速率是调节淀粉酶与脂肪酶比例的主要因素。
