Yang X, Hyder F, Shulman R G
Department of Chemistry, Yale University, New Haven, Connecticut 06520-8043, USA.
Magn Reson Med. 1997 Dec;38(6):874-7. doi: 10.1002/mrm.1910380604.
Functional MRI (fMRI) provides a noninvasive method for mapping brain functional activity based on blood oxygenation level dependent (BOLD) image contrast that is primarily due to localized increases in perfusion. Recently, Malonek and Grinvald (Science 272:551-554, 1996) suggested that during sustained functional activation, the increases in perfusion were spread over a much larger area than the localized electrical activity. In this study, it is demonstrated that the spatial distribution of the BOLD fMRI signal during sustained stimulation of rat whiskers has the same spatial pattern and dimension as that of neuronal electrical activity in the rat whisker barrels.
功能磁共振成像（fMRI）提供了一种基于血氧水平依赖（BOLD）图像对比度来绘制大脑功能活动的非侵入性方法，这种对比度主要是由于局部灌注增加所致。最近，马洛内克和格林瓦尔德（《科学》272:551 - 554，1996）提出，在持续功能激活期间，灌注增加所覆盖的区域比局部电活动大得多。在本研究中，结果表明，在持续刺激大鼠胡须期间，BOLD fMRI信号的空间分布与大鼠胡须桶状区神经元电活动的空间模式和维度相同。
