Guarro J, Gams W, Pujol I, Gené J
Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Reus, Spain.
Clin Infect Dis. 1997 Nov;25(5):1222-9. doi: 10.1086/516098.
We provide an overview of opportunistic fungal infections caused by Acremonium (Cephalosporium) species and discuss the classification of these species as well as the diagnosis and treatment of acremonium infections. We used a microdilution broth method to compare in vitro susceptibilities and minimum inhibitory concentrations and minimum fungicidal concentrations of amphotericin B, miconazole, itraconazole, 5-fluorocytosine, fluconazole, and ketoconazole for 33 clinical and environmental isolates of Acremonium. In general, the isolates tested displayed little susceptibility to the antifungals tested. Fluconazole and 5-fluorocytosine were ineffective in all cases. The efficacy of the remaining drugs was dependent on the strain. Amphotericin B showed the best results.
我们概述了枝顶孢属（头孢霉属）物种引起的机会性真菌感染，并讨论了这些物种的分类以及枝顶孢属感染的诊断和治疗。我们采用微量稀释肉汤法比较了两性霉素B、咪康唑、伊曲康唑、5-氟胞嘧啶、氟康唑和酮康唑对33株临床和环境来源的枝顶孢属菌株的体外敏感性、最低抑菌浓度和最低杀菌浓度。总体而言，所测试的菌株对所测试的抗真菌药物敏感性较低。氟康唑和5-氟胞嘧啶在所有情况下均无效。其余药物的疗效取决于菌株。两性霉素B显示出最佳效果。
