年龄对比格幼犬甲状腺131I摄取的影响。
Influence of age on thyroidal 131I uptake in Beagle pups.
作者信息
Book S A
出版信息
Lab Anim Sci. 1976 Jun;26(3):443-9.
Parameters in radioiodine metabolism by the thyroid gland were investigated in 98 beagle pups 0-110 da of age and in 6 adults. Significant age-related differences in thyroidal 131I uptake, uptake/g of thyroid, and retention and subsequent radiation dose were observed. Significant differences were also found in uptake/g, retention and subsequent radiation dose were observed. Significant differences were also found in uptake/g, retention, and dose between litters of the same age. Seventy-da-old pups had the highest mean uptake (approximately 25% of the administered dose) and fastest release rate (effective half-life approximately 3.6 da), whereas neonates less than 12 hr of age showed the highest peak concentration (157% of administered dose/g thyroid). The calculated radiation doses to the thyroid were highest in newborn pups, averaging over 100 rads per microcurie of 131I administered, or about 10 times the dose/muCi for adults.
对98只0至110日龄的比格幼犬和6只成年犬的甲状腺放射性碘代谢参数进行了研究。观察到甲状腺对131I的摄取、每克甲状腺摄取量、滞留量及随后的辐射剂量存在显著的年龄相关差异。在每克摄取量、滞留量及随后的辐射剂量方面也发现了显著差异。在同一年龄的不同窝幼犬之间，每克摄取量、滞留量和剂量也存在显著差异。70日龄的幼犬平均摄取量最高（约为给药剂量的25%），释放速度最快（有效半衰期约为3.6天），而小于12小时龄的新生儿甲状腺峰值浓度最高（每克甲状腺为给药剂量的157%）。计算得出新生幼犬甲状腺的辐射剂量最高，每微居里131I给药平均超过100拉德，约为成年犬每微居里剂量的10倍。
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