嗜肺军团菌1血清型脂多糖内核区域中α-D-甘露糖基-（1→8）-Kdo二糖的鉴定及完整核心区域的结构
Identification of an alpha-D-Manp-(1-->8)-Kdo disaccharide in the inner core region and the structure of the complete core region of the Legionella pneumophila serogroup 1 lipopolysaccharide.
作者信息
Moll H, Knirel Y A, Helbig J H, Zähringer U
机构信息
Forschungszentrum Borstel, Zentrum für Medizin und Biowissenschaften, Borstel, Germany.
出版信息
Carbohydr Res. 1997 Oct 28;304(1):91-5. doi: 10.1016/s0008-6215(97)00210-3.
A disaccharide alpha-D-mannopyranosyl-(1-->8)-3-deoxy-D-manno-octulosonic acid [alpha-D-Manp-(1-->8)-Kdo] was released by mild acid degradation of Legionella pneumophila serogroup 1 (strain Philadelphia 1) lipopolysaccharide (LPS) and identified using NMR spectroscopy and GLC-MS of derived products. These data, together with methylation analysis of the native LPS and previously reported data [Y.A. Knirel, H. Moll, and U. Zähringer, Carbohydr. Res., 293 (1996) 223-234], allowed elucidation of the complete core region of the LPS as having the following nonasaccharide structure: [Sequence: see text]
通过对嗜肺军团菌血清1型（费城1株）脂多糖（LPS）进行温和酸降解，释放出一种二糖α-D-甘露吡喃糖基-(1→8)-3-脱氧-D-甘露辛酮糖酸[α-D-Manp-(1→8)-Kdo]，并使用衍生产品的核磁共振光谱和气相色谱-质谱联用技术进行鉴定。这些数据，连同天然LPS的甲基化分析和先前报道的数据[Y.A. 克尼雷尔、H. 莫尔和U. 察林格，《碳水化合物研究》，293 (1996) 223 - 234]，使得能够阐明LPS完整核心区域具有以下九糖结构：[序列：见正文]
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