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PPARalpha and PPARgamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene.过氧化物酶体增殖物激活受体α（PPARα）和过氧化物酶体增殖物激活受体γ（PPARγ）激活剂通过脂蛋白脂肪酶基因中的过氧化物酶体增殖物反应元件（PPRE）引导不同的组织特异性转录反应。
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Induction of peroxisome proliferator-activated receptor gamma during the conversion of 3T3 fibroblasts into adipocytes is mediated by C/EBPbeta, C/EBPdelta, and glucocorticoids.在3T3成纤维细胞向脂肪细胞转化过程中，过氧化物酶体增殖物激活受体γ的诱导由C/EBPβ、C/EBPδ和糖皮质激素介导。
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15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma.15-脱氧-Δ12,14-前列腺素J2是脂肪细胞决定因子PPARγ的一种配体。
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缺乏C/EBPβ和/或C/EBPδ基因的小鼠脂肪细胞分化存在缺陷。

Defective adipocyte differentiation in mice lacking the C/EBPbeta and/or C/EBPdelta gene.

作者信息

Tanaka T, Yoshida N, Kishimoto T, Akira S

机构信息

Department of Biochemistry, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663, Japan.

出版信息

EMBO J. 1997 Dec 15;16(24):7432-43. doi: 10.1093/emboj/16.24.7432.

DOI:10.1093/emboj/16.24.7432
PMID:9405372
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1170343/
Abstract

To investigate the role of C/EBP family members during adipocyte differentiation in vivo, we have generated mice lacking the C/EBPbeta and/or C/EBPdelta by gene targeting. Approximately 85% of C/EBPbeta(-/-).delta(-/-) mice died at the early neonatal stage. By 20 h after birth, brown adipose tissue of the interscapular region in wild-type mice contained many lipid droplets, whereas C/EBPbeta(-/-).delta(-/-) mice did not accumulate droplets. In addition, the epidydimal fat pad weight of surviving adult C/EBPbeta(-/-).delta(-/-) mice was significantly reduced compared with wild-type mice. However, these adipose tissues in C/EBPbeta(-/-).delta(-/-) mice exhibit normal expression of C/EBPalpha and PPARgamma, despite impaired adipogenesis. These results demonstrated that C/EBPbeta and C/EBPdelta have a synergistic role in terminal adipocyte differentiation in vivo. The induction of C/EBPalpha and PPARgamma does not always require C/EBPbeta and C/EBPdelta, but co-expression of C/EBPalpha and PPARgamma is not sufficient for complete adipocyte differentiation in the absence of C/EBPbeta and C/EBPdelta.

摘要

为了研究C/EBP家族成员在体内脂肪细胞分化过程中的作用，我们通过基因打靶技术培育出了缺乏C/EBPβ和/或C/EBPδ的小鼠。大约85%的C/EBPβ(-/-).δ(-/-)小鼠在新生儿早期死亡。出生后20小时，野生型小鼠肩胛间区域的棕色脂肪组织含有许多脂滴，而C/EBPβ(-/-).δ(-/-)小鼠没有积累脂滴。此外，存活的成年C/EBPβ(-/-).δ(-/-)小鼠的附睾脂肪垫重量与野生型小鼠相比显著降低。然而，尽管脂肪生成受损，但C/EBPβ(-/-).δ(-/-)小鼠的这些脂肪组织中C/EBPα和PPARγ的表达正常。这些结果表明，C/EBPβ和C/EBPδ在体内终末脂肪细胞分化中具有协同作用。C/EBPα和PPARγ的诱导并不总是需要C/EBPβ和C/EBPδ，但在没有C/EBPβ和C/EBPδ的情况下，C/EBPα和PPARγ的共表达不足以实现完全的脂肪细胞分化。