Mendelson W B
Sleep Research Laboratory, University of Chicago, IL 60637, USA.
J Biol Rhythms. 1997 Dec;12(6):651-6. doi: 10.1177/074873049701200621.
The seemingly contradictory literature on the use of melatonin in insomnia is best understood by considering issues of time of administration (day or night), dose range (physiological or pharmacological), subject selection (normals or insomniacs), choice of dependent variable (self-report or electroencephalogram), and comprehensiveness of the reported variables (sleep onset or sleep maintenance). Available data on nighttime administration to normals and insomniacs are reviewed. It is concluded that there is not yet a convincing body of evidence, using generally accepted measures, that melatonin administration improves sleep in insomniacs with noncircadian sleep disturbance.
关于褪黑素在失眠治疗中的应用，那些看似矛盾的文献，通过考虑给药时间（白天或晚上）、剂量范围（生理剂量或药理剂量）、受试者选择（正常人或失眠患者）、因变量的选择（自我报告或脑电图）以及所报告变量的全面性（入睡或睡眠维持）等问题，能得到最好的理解。本文回顾了关于对正常人和失眠患者进行夜间给药的现有数据。得出的结论是，使用普遍接受的测量方法，目前尚无确凿的证据表明，对于患有非昼夜节律性睡眠障碍的失眠患者，服用褪黑素能改善其睡眠。
