Mendelson W B
Sleep Research Laboratory, University of Chicago, Illinois, USA.
Sleep. 1997 Oct;20(10):916-9. doi: 10.1093/sleep/20.10.916.
This paper reviews the available literature on the use of melatonin as a hypnotic in normal volunteers and in patients with noncircadian insomnias. Data are ordered in terms of studies of subject self-reports and polygraphic data and are seen in the context of generally accepted criteria for assessment of clinically used hypnotics. It is concluded that, at the present time, there is very little systematic evidence to suggest that melatonin has significant hypnotic efficacy in these populations.
本文综述了褪黑素作为催眠药在正常志愿者和非昼夜节律性失眠患者中应用的现有文献。数据按照受试者自我报告研究和多导睡眠图数据进行整理，并结合临床使用催眠药评估的普遍公认标准进行分析。结论是，目前几乎没有系统的证据表明褪黑素在这些人群中具有显著的催眠效果。
