10号染色体三体：年龄与白血病谱系关联
Trisomy 10: age and leukemic lineage associations.
作者信息
Morgan R, Chen Z, Stone J F, Cohen J, Gustafson E, Jolly P C, Sandberg A A
机构信息
SBRI and Genetrix, Inc., Scottsdale, Arizona 85251, USA.
出版信息
Cancer Genet Cytogenet. 1996 Jul 15;89(2):173-4. doi: 10.1016/0165-4608(96)00075-1.
We observed three cases of acute leukemia with trisomy 10 (+10) as the sole abnormality, two were adult patients with ANLL (subtype M0 and M1 respectively), and the third that of a child with ALL. The literature describes nine additional cases, four with ALL (all of whom were children) and five with ANLL (all of whom were adults). Cell marker studies on the ANLL cases showed a common positivity for CD7 and CD33 in our two cases, as well as in four of the previously reported cases, whereas in ALL the only two informative cases were classified as early pre-B ALL. There appears to be an age-related pattern in the specificity of the leukemic lineage. Trisomy 10 appears to be associated exclusively with ALL in children and with ANLL (usually M0-M1) in adults. The prognosis appears to be also divided between the two groups, being good in the pediatric group and moderate in the adult group.
我们观察到3例急性白血病患者，其唯一异常为10号染色体三体（+10），其中2例为成年急性非淋巴细胞白血病（ANLL）患者（分别为M0和M1亚型），第3例为1例患急性淋巴细胞白血病（ALL）的儿童。文献中还描述了另外9例病例，其中4例为ALL（均为儿童），5例为ANLL（均为成人）。对ANLL病例的细胞标志物研究显示，我们的2例病例以及之前报道的4例病例中CD7和CD33均呈阳性，而在ALL中，仅有的2例可提供信息的病例被归类为早期前B-ALL。白血病谱系的特异性似乎存在与年龄相关的模式。10号染色体三体似乎仅与儿童ALL以及成人ANLL（通常为M0-M1）相关。两组的预后似乎也有所不同，儿科组预后良好，成人组预后中等。
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