Miyamoto Y, Ishikawa K, Takechi M, Toh T, Yoshida Y, Nagayama M, Kon M, Asaoka K
First Department of Oral and Maxillofacial Surgery, School of Dentistry, Tokushima University, Japan.
J Biomed Mater Res. 1997 Dec 15;37(4):457-64. doi: 10.1002/(sici)1097-4636(19971215)37:4<457::aid-jbm3>3.0.co;2-k.
Fast-setting calcium phosphate cement (FSCPC) is a promising new bioactive cement with a significantly short setting time (approximately 5-6 min) compared to conventional calcium phosphate cement (c-CPC) (30-60 min) at physiologic temperatures. As a result of its ability to set quickly, it is applicable in surgical procedures where fast setting is required. In this study, FSCPC was implanted in rat tibiae to evaluate tissue response and biocompatibility. FSCPC was converted to hydroxyapatite (HAP) in bone faster than c-CPC in the first 6 h. By 24 h, significant amounts of both FSCPC and c-CPC had been converted to HAP. The conversion of FSCPC into HAP further proceeded gradually, reaching 100% within 8 weeks. Infrared spectroscopic analysis disclosed the deposition of B-type carbonate apatite, which is a biological apatite contained in human dentin or bone, on the surface of the FSCPC. Histologically, FSCPC showed a tissue response similar to that of c-CPC. A slight inflammatory reaction was observed in the soft tissue apposed to both cements in the early period, and new bone was formed along the surface of the FSCPC at the adjacent bone. However, no resorption of either cement by osteoclasts or macrophages was observed within 8 weeks. We conclude that FSCPC is superior to c-CPC in clinical applications in oral and maxillofacial, orthopedic, plastic, and reconstructive surgery, since it shows a faster setting time and higher mechanical strength in the early period that are required in these surgical procedures, as well as osteoconductivity and excellent biocompatibility similar to that of c-CPC.
快凝磷酸钙骨水泥（FSCPC）是一种很有前景的新型生物活性骨水泥，与传统磷酸钙骨水泥（c-CPC）相比，在生理温度下其凝固时间显著缩短（约5-6分钟），而c-CPC的凝固时间为30-60分钟。由于其能够快速凝固，适用于需要快速凝固的外科手术。在本研究中，将FSCPC植入大鼠胫骨以评估组织反应和生物相容性。在最初6小时内，FSCPC在骨中比c-CPC更快地转化为羟基磷灰石（HAP）。到24小时时，大量的FSCPC和c-CPC都已转化为HAP。FSCPC向HAP的转化进一步逐渐进行，在8周内达到100%。红外光谱分析揭示了B型碳酸磷灰石（一种存在于人类牙本质或骨骼中的生物磷灰石）在FSCPC表面的沉积。组织学上，FSCPC显示出与c-CPC相似的组织反应。在早期，在与两种骨水泥相邻的软组织中观察到轻微的炎症反应，并且在相邻骨处沿着FSCPC表面形成了新骨。然而，在8周内未观察到破骨细胞或巨噬细胞对任何一种骨水泥的吸收。我们得出结论，FSCPC在口腔颌面、骨科、整形和重建外科的临床应用中优于c-CPC，因为它显示出更快的凝固时间和在这些外科手术所需的早期更高的机械强度，以及与c-CPC相似的骨传导性和优异的生物相容性。
