Ishikawa K, Miyamoto Y, Kon M, Nagayama M, Asaoka K
Department of Dental Engineering, School of Dentistry, Tokushima University, Japan.
Biomaterials. 1995 May;16(7):527-32. doi: 10.1016/0142-9612(95)91125-i.
Non-decay type fast-setting calcium phosphate cement (nd-FSCPC) was prepared by introducing sodium alginate (0-2.0 wt%) into the liquid phase of FSCPC. nd-FSCPC was stable even when the cement paste was immersed in distilled water immediately after mixing, whereas conventional FSCPC (c-FSCPC) decayed completely within 1 min upon immersion. The setting time of the cement, approximately 5 min, was not dependent on the presence of sodium alginate. In contrast, the introduction of sodium alginate into conventional CPC, i.e. CPC without neutral phosphate in the liquid phase, resulted in no setting when the amount of sodium alginate introduced was more than 1 wt%. Powder X-ray diffraction analysis revealed no significant difference for the conversion of cement to apatite for any concentrations of sodium alginate studied (0-2.0 wt%). The mechanical strength of the cement increased rapidly with the addition of sodium alginate up to 0.8 wt% when the cement paste was immersed and kept in distilled water at 37 degrees C, whereas further addition of sodium alginate decreased the mechanical strength. The results obtained in this investigation, taken together with sodium alginate's known excellent biocompatibility and absorption behaviour, indicate that the use of sodium alginate composite FSCPC as nd-FSCPC should be of value in orthodontics and oral and maxillofacial surgery where the cement is exposed to blood.
通过将海藻酸钠（0 - 2.0 wt%）引入快凝磷酸钙骨水泥（FSCPC）的液相中来制备非降解型快凝磷酸钙骨水泥（nd - FSCPC）。即使在混合后立即将水泥浆体浸入蒸馏水中，nd - FSCPC仍保持稳定，而传统的FSCPC（c - FSCPC）浸入后1分钟内就会完全降解。该水泥的凝结时间约为5分钟，不依赖于海藻酸钠的存在。相比之下，将海藻酸钠引入传统的磷酸钙骨水泥（CPC）中，即在液相中不含中性磷酸盐的CPC中，当引入的海藻酸钠量超过1 wt%时不会发生凝结。粉末X射线衍射分析表明，在所研究的任何海藻酸钠浓度（0 - 2.0 wt%）下，水泥向磷灰石的转化没有显著差异。当水泥浆体浸入并保持在37℃的蒸馏水中时，随着海藻酸钠添加量增加至0.8 wt%，水泥的机械强度迅速增加，而进一步添加海藻酸钠则会降低机械强度。本研究获得的结果，结合海藻酸钠已知的优异生物相容性和吸收行为，表明使用海藻酸钠复合FSCPC作为nd - FSCPC在正畸以及水泥暴露于血液的口腔颌面外科手术中应具有价值。
