Takechi M, Miyamoto Y, Ishikawa K, Toh T, Yuasa T, Nagayama M, Suzuki K
First Department of Oral and Maxillofacial Surgery, School of Dentistry, Tokushima University, Japan.
Biomaterials. 1998 Nov;19(22):2057-63. doi: 10.1016/s0142-9612(98)00114-8.
Anti-washout-type fast-setting calcium phosphate cement using chitosan (aw-FSCPC(chi)), conventional CPC (c-CPC), CPC mixed with citric acid (CPC(citric)) and CPC mixed with polyacrylic acid (CPC(acrylic)) were implanted subcutaneously in rats immediately after mixing to shed some light on the understanding of the appearance of excellent tissue response to CPC. CPC(citric) and CPC(acrylic) set quickly, similar to aw-FSCPC(chi), but the former two stopped their transformation to apatitic minerals. The c-CPC, which required a long setting time, was found to be crumbled, but the other CPCs maintained the shape at implantation. The aw-FSCPC(chi) and CPC(citric) showed no inflammatory response whereas c-CPC and CPC(acrylic) showed an inflammatory response one week after implantation. A component of the aw-FSCPC(chi) and c-CPC was an apatitic mineral whereas CPC(citric) and CPC(acrylic) showed no transformation to apatite. We concluded that the non-crumbling property plays a more dominant role in the appearance of excellent tissue response to CPC than the transformation to apatite. Also, a non-crumbling property is not a sufficient condition, but a necessary condition for the appearance of the excellent tissue response to CPC.
壳聚糖抗冲洗型速凝磷酸钙骨水泥（aw-FSCPC(chi)）、传统磷酸钙骨水泥（c-CPC）、与柠檬酸混合的磷酸钙骨水泥（CPC(柠檬酸)）以及与聚丙烯酸混合的磷酸钙骨水泥（CPC(丙烯酸)）在混合后立即皮下植入大鼠体内，以进一步了解对磷酸钙骨水泥产生优异组织反应的原因。CPC(柠檬酸)和CPC(丙烯酸)凝固迅速，与aw-FSCPC(chi)相似，但前两者停止向磷灰石矿物转化。凝固时间长的c-CPC被发现会破碎，而其他磷酸钙骨水泥在植入时保持形状。aw-FSCPC(chi)和CPC(柠檬酸)在植入后一周未显示炎症反应，而c-CPC和CPC(丙烯酸)显示有炎症反应。aw-FSCPC(chi)和c-CPC的一种成分是磷灰石矿物，而CPC(柠檬酸)和CPC(丙烯酸)未显示向磷灰石的转化。我们得出结论，在对磷酸钙骨水泥产生优异组织反应方面，不破碎特性比向磷灰石的转化起更主导的作用。此外，不破碎特性不是产生对磷酸钙骨水泥优异组织反应的充分条件，而是必要条件。
