Miyamoto Y, Ishikawa K, Fukao H, Sawada M, Nagayama M, Kon M, Asaoka K
First Department of Oral and Maxillofacial Surgery, School of Dentistry, Tokushima University, Japan.
Biomaterials. 1995 Jul;16(11):855-60. doi: 10.1016/0142-9612(95)94147-d.
The in vivo setting behaviour of fast-setting calcium phosphate cement (FSCPC) between femoral muscles of the rat was investigated to evaluate the possible value of FSCPC for medical and dental application. Conventional CPC (c-CPC) and FSCPC were implanted between femoral muscles, and various aspects of the setting behaviour such as setting time, mechanical strength and conversion ratio of cement into hydroxyapatite (HAP: Ca10(PO4)6(OH)2) were measured by the Vicat needle method, diametral tensile strength (DTS) measurement, and quantitative powder X-ray diffraction (XRD) analysis, respectively. The setting time of FSCPC in vivo was 5-7 min, in contrast to 48 min for c-CPC. As a result of its fast setting, set specimens of FSCPC showed higher mechanical strength from the initial stage than c-CPC. Higher DTS values were observed in FSCPC than c-CPC implanted after 24 h. Powder XRD analysis revealed faster conversion of FSCPC than c-CPC into HAP, which was responsible both for the faster setting and higher mechanical strength from the initial stage. We concluded, therefore, that FSCPC may be used for a wide range of clinical applications, i.e. fields where fast setting is required such as orthopaedic, plastic and reconstructive, and oral and maxillofacial surgery.
为评估快凝磷酸钙骨水泥（FSCPC）在医学和牙科应用中的潜在价值，研究了其在大鼠股肌间的体内凝固行为。将传统骨水泥（c-CPC）和FSCPC植入股肌间，分别采用维卡针法、径向拉伸强度（DTS）测量和定量粉末X射线衍射（XRD）分析来测定凝固行为的各个方面，如凝固时间、机械强度以及骨水泥向羟基磷灰石（HAP：Ca10(PO4)6(OH)2）的转化率。FSCPC在体内的凝固时间为5 - 7分钟，而c-CPC为48分钟。由于其快速凝固，FSCPC凝固后的标本从初始阶段就显示出比c-CPC更高的机械强度。在植入24小时后，观察到FSCPC的DTS值高于c-CPC。粉末XRD分析表明，FSCPC比c-CPC更快地转化为HAP，这既导致其凝固更快，也使其从初始阶段就具有更高的机械强度。因此，我们得出结论，FSCPC可用于广泛的临床应用，即在需要快速凝固的领域，如骨科、整形与重建外科以及口腔颌面外科。
