Walker E A, Keegan D, Gardner G, Sullivan M, Katon W J, Bernstein D
Department of Psychiatry, University of Washington, Seattle 98195, USA.
Psychosom Med. 1997 Nov-Dec;59(6):565-71. doi: 10.1097/00006842-199711000-00002.
Recent studies of the relationship between fibromyalgia and psychiatric disorders have yielded conflicting findings, and many of these inconsistencies seem to result from methodological differences.
We compared 36 patients with fibromyalgia and 33 patients with rheumatoid arthritis from a tertiary care clinic using physician-administered, structured psychiatric interviews and self-reported measures of illness appraisal, coping, and functional disability.
Patients with fibromyalgia had significantly higher lifetime prevalence rates of mood and anxiety disorders, as well as higher mean numbers of medically unexplained physical symptoms across several organ systems. Ninety percent of the patients with fibromyalgia had a prior psychiatric diagnosis compared with less than half of the patients with rheumatoid arthritis.
Despite the absence of organic pathology, the patients with fibromyalgia had equal or greater functional disability and were less well adapted to their illness. Although the pathophysiology of fibromyalgia remains unclear, co-morbid psychiatric disorders and functional disability remain an important focus of treatment in this population.
近期关于纤维肌痛与精神障碍之间关系的研究结果相互矛盾,其中许多不一致似乎源于方法学差异。
我们使用医生实施的结构化精神访谈以及自我报告的疾病评估、应对和功能残疾测量方法,对一家三级护理诊所的36例纤维肌痛患者和33例类风湿性关节炎患者进行了比较。
纤维肌痛患者的心境和焦虑障碍终生患病率显著更高,并且在多个器官系统中,医学上无法解释的身体症状的平均数量也更多。90%的纤维肌痛患者曾有过精神科诊断,而类风湿性关节炎患者中这一比例不到一半。
尽管没有器质性病变,但纤维肌痛患者存在同等或更大的功能残疾,并且对疾病的适应能力较差。虽然纤维肌痛的病理生理学仍不清楚,但共病的精神障碍和功能残疾仍是该人群治疗的重要重点。