Rodriguez M, Ahlström H, Sundín A, Rehn S, Sundström C, Hagberg H, Glimelius B
Department of Diagnostic Radiology, University of Uppsala, Akademiska Sjukhuset, Sweden.
Acta Oncol. 1997;36(6):577-84. doi: 10.3109/02841869709001319.
The possibility of using [18F] FDG PET for assessment of tumor extension in primary gastric non-Hodgkin's lymphoma (NHL) was studied in 8 patients (6 high-grade and 2 low-grade, one of the MALT type) and in a control group of 7 patients (5 patients with NHL without clinical signs of gastric involvement, 1 patient with NHL and benign gastric ulcer and 1 patient with adenocarcinoma of the stomach). All patients with gastric NHL and the two with benign gastric ulcer and adenocarcinoma, respectively, underwent endoscopy including multiple biopsies for histopathological diagnosis. All patients with high-grade and one of the two with low-grade NHL and the patient with adenocarcinoma displayed high gastric uptake of [18F] FDG corresponding to the pathological findings at endoscopy and/or CT. No pathological tracer uptake was seen in the patient with low-grade gastric NHL of the MALT type. In 6/8 patients with gastric NHL, [18F] FDG PET demonstrated larger tumor extension in the stomach than was found at endoscopy, and there was high tracer uptake in the stomach in two patients who were evaluated as normal on CT. [18F] FDG PET correctly excluded gastric NHL in the patient with a benign gastric ulcer and in the patients with NHL without clinical signs of gastric involvement. Although the experience is as yet limited, [18F] FDG PET affords a novel possibility for evaluation of gastric NHL and would seem valuable as a complement to endoscopy and CT in selected patients, where the technique can yield additional information decisive for the choice of therapy.
对8例原发性胃非霍奇金淋巴瘤（NHL）患者（6例高级别、2例低级别，其中1例为MALT型）以及7例对照组患者（5例无胃受累临床体征的NHL患者、1例NHL合并良性胃溃疡患者和1例胃腺癌患者）研究了使用[18F]氟代脱氧葡萄糖正电子发射断层显像（FDG PET）评估原发性胃NHL肿瘤范围的可能性。所有胃NHL患者以及分别患有良性胃溃疡和腺癌的2例患者均接受了内镜检查，包括多次活检以进行组织病理学诊断。所有高级别NHL患者、2例低级别NHL患者中的1例以及腺癌患者胃内均显示出[18F] FDG的高摄取，与内镜检查和/或CT的病理结果相符。MALT型低级别胃NHL患者未见病理性示踪剂摄取。在8例胃NHL患者中的6例中，[18F] FDG PET显示胃内肿瘤范围比内镜检查发现的更大，并且在CT检查评估为正常的2例患者胃内有高示踪剂摄取。[18F] FDG PET正确排除了良性胃溃疡患者以及无胃受累临床体征的NHL患者的胃NHL。尽管经验有限，但[18F] FDG PET为评估胃NHL提供了一种新的可能性，并且在某些患者中作为内镜检查和CT的补充似乎很有价值，该技术可以提供对治疗选择具有决定性作用的额外信息。
