Garlick P B, Marsden P K, Cave A C, Parkes H G, Slates R, Shao Y, Silverman R W, Cherry S R
UMDS, Guy's and St Thomas' Hospital, London, UK.
NMR Biomed. 1997 May;10(3):138-42. doi: 10.1002/(sici)1099-1492(199705)10:3<138::aid-nbm474>3.0.co;2-h.
Positron emission tomography and nuclear magnetic resonance spectroscopy are non-invasive techniques that allow serial metabolic measurements to be obtained in a single subject. Significant advantages could be obtained if both types of scans could be acquired with a single machine. A small-scale PET scanner, designed to operate in a high magnetic field, was therefore constructed and inserted into the top half of a 7.3 cm bore, 9.4 T NMR magnet and its performance characterized. The magnetic field did not significantly affect either the sensitivity (approximately 3 kcps/MBq) or the spatial resolution (2.0 mm full width at half maximum, measured using a 0.25 mm diameter line source) of the scanner. However, the presence of the PET scanner resulted in a small decrease in field homogeneity. The first, simultaneous 31P NMR spectra (200, 80 degrees pulses collected at 6 s intervals) and PET images (transverse, mid-ventricular slices at the level of the mitral value) from isolated, perfused rat hearts were acquired using a specially designed NMR probe inserted into the bottom half of the magnet. The PET images were of excellent quality, enabling the left ventricular wall and interventricular septum to be clearly seen. In conclusion, we have demonstrated the simultaneous acquisition of PET and NMR data from perfused rat hearts; we believe that the combination of these two powerful techniques has tremendous potential in both the laboratory and the clinic.
正电子发射断层扫描和核磁共振波谱是无创技术，可在单个受试者身上进行系列代谢测量。如果能用一台机器同时进行这两种扫描，将会带来显著的优势。因此，我们制造了一台设计用于在高磁场中运行的小型正电子发射断层扫描仪，并将其安装在一台7.3厘米孔径、9.4特斯拉的核磁共振磁体的上半部分，并对其性能进行了表征。磁场对扫描仪的灵敏度（约3千计数每秒每兆贝可）或空间分辨率（半高宽为2.0毫米，使用直径0.25毫米的线源测量）没有显著影响。然而，正电子发射断层扫描仪的存在导致磁场均匀性略有下降。使用插入磁体下半部分的特制核磁共振探头，首次从离体灌注大鼠心脏同时采集了31P核磁共振波谱（以6秒间隔采集200个、80度脉冲）和正电子发射断层图像（二尖瓣水平的横向心室中部切片）。正电子发射断层图像质量极佳，能清晰看到左心室壁和室间隔。总之，我们已经证明可以从灌注大鼠心脏同时采集正电子发射断层和核磁共振数据；我们相信，这两种强大技术的结合在实验室和临床都具有巨大潜力。
