Augustin M, Dieterle W, Zschocke I, Brill C, Trefzer D, Peschen M, Schöpf E, Vanscheidt W
Universitätshautklinik, Freiburg.
Vasa. 1997 Nov;26(4):291-301.
Recording of Quality of Life (QoL) is taking on increasing importance in medicine. Although QoL cannot be measured directly, numerous methods studies have demonstrated that important areas of QoL can be addressed by validated questionnaires. The present study was designed to examine a new disease-specific, German-language questionnaire, the Freiburger Questionnaire of QoL in venous diseases (FLQA), with respect to reliability, validity and patient acceptance-among patients with chronic venous insufficiency (CVI).
The FLQA consists of 83 items and differentiates between limitations in QoL in 7 scales: physical complaints, everyday life, social life, emotional status, therapy, satisfaction, occupation. Data were collected from 246 patients with CVI stage I (n = 107), II (n = 75) and III (venous ulcer, n = 64) in the Widmer classification.
In the psychometric test, the majority of scales showed little or no top or bottom effect. The internal consistency of the scales was generally high (Cronbach's Alpha in all scales more than alpha = .70 and in 4 scales above alpha = .90). The convergent validity with the Nottingham Health Profile and the ALLTAG was high in several scales. The FLQA showed good discriminant validity and significantly differentiated between the clinical CVI stages in several areas of QoL. The change sensitivity during the course of therapy was also good. In a feasibility test, the acceptance values among patients were high with respect to ease of understanding and description of the QoL areas relevant to them. The mean time to fill out the questionnaire was 21 +/- 6 minutes.
Overall, the FLQA appears suitable to reliably record characteristics of QoL in patients with CVI in both course and cross-sectional studies.
生活质量（QoL）记录在医学领域正变得越来越重要。尽管生活质量无法直接测量，但大量方法学研究表明，经过验证的问卷可以涵盖生活质量的重要方面。本研究旨在针对一种新的、特定疾病的德语问卷——静脉疾病生活质量弗赖堡问卷（FLQA），在慢性静脉功能不全（CVI）患者中检验其信度、效度和患者接受度。
FLQA由83个项目组成，在7个量表中区分生活质量的限制因素：身体不适、日常生活、社交生活、情绪状态、治疗、满意度、职业。数据收集自246例根据维德默分类法处于I期（n = 107）、II期（n = 75）和III期（静脉溃疡，n = 64）的CVI患者。
在心理测量测试中，大多数量表显示出很少或没有上限或下限效应。量表的内部一致性普遍较高（所有量表的克朗巴哈α系数均大于α = 0.70，4个量表大于α = 0.90）。在几个量表中，与诺丁汉健康量表和ALLTAG的收敛效度较高。FLQA显示出良好的区分效度，并且在生活质量的几个方面能够显著区分临床CVI分期。治疗过程中的变化敏感性也较好。在可行性测试中，患者对问卷的接受度较高，因为问卷易于理解，并且能够描述与他们相关的生活质量方面。填写问卷的平均时间为21±6分钟。
总体而言，FLQA似乎适合在纵向和横断面研究中可靠地记录CVI患者的生活质量特征。
