Edwards-Brown M K, Quets J P
Department of Radiology, Indiana University School of Medicine, Riley Hospital, Indianapolis 46202, USA.
Clin Neurol Neurosurg. 1997 Oct;99 Suppl 2:S36-8. doi: 10.1016/s0303-8467(97)00038-3.
A review of the cases of Moyamoya disease at two large Mid-Western United States Universities was undertaken for the purpose of assessing the epidemiology of Moyamoya disease. A total of 51 cases of Moyamoya disease were identified, with 12 cases classified as akin Moyamoya disease, nine cases of probable Moyamoya disease, and 30 cases of classic or definite Moyamoya disease. The conditions associated with akin Moyamoya were sickle cell disease, Down's syndrome, trauma, radiation, and neurofibromatosis. The mean age of presentation for probable and classic Moyamoya disease was 22 years. The sex predilection was approximately equal, with a slight female predominance. The racial background was identified in 22 of the definite cases, and included six patients with oriental inheritance, three with American Indian inheritance, one black, and the remainder Caucasian. Of some interest, there were five Caucasian patients with names identifiable as Eastern European in origin. The mean age of presentation of the definite Moyamoya disease was 14 years, the probable Moyamoya disease was 4 years, and the akin Moyamoya disease was 5 years.
为评估烟雾病的流行病学情况，对美国中西部两所大型大学的烟雾病病例进行了回顾。共识别出51例烟雾病病例，其中12例归类为类烟雾病，9例为疑似烟雾病，30例为典型或确诊烟雾病。与类烟雾病相关的疾病有镰状细胞病、唐氏综合征、创伤、辐射和神经纤维瘤病。疑似和典型烟雾病的平均发病年龄为22岁。性别倾向大致相等，女性略占优势。在22例确诊病例中确定了种族背景，其中包括6例有东方人遗传背景的患者、3例有美洲印第安人遗传背景的患者、1例黑人患者，其余为白种人。有趣的是，有5名白种人患者的名字可确定起源于东欧。确诊烟雾病的平均发病年龄为14岁，疑似烟雾病为4岁，类烟雾病为5岁。
